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Literature summary for 1.14.19.17 extracted from

  • Poliakov, E.; Samuel, W.; Duncan, T.; Gutierrez, D.B.; Mata, N.L.; Redmond, T.M.
    Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets beta-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide DELTA4-desaturase 1 (2017), PLoS ONE, 12, e0176487 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development enzyme DES1 inhibition is used in treatment of cancer Mus musculus
drug development enzyme DES1 inhibition is used in treatment of cancer, it is a target for fenretinide and fenretinide metabolites Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-oxo-N-(4-hydroxyphenyl)retinamide
-
 Homo sapiens
4-oxo-N-(4-hydroxyphenyl)retinamide leads to an increase in C16 and C18 dihydroceramide substrate accumulation Mus musculus
fenretinide i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation Homo sapiens
fenretinide i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation Mus musculus
additional information no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively Homo sapiens
additional information no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O15121
-
-
Mus musculus O09005
-
-
Mus musculus C57BL/6 O09005
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ARPE-19 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Degs1
-
 Homo sapiens
Degs1
-
 Mus musculus
DES1
-
 Homo sapiens
DES1
-
 Mus musculus
dihydroceramide DELTA4-desaturase 1
-
 Homo sapiens
dihydroceramide DELTA4-desaturase 1
-
 Mus musculus

General Information

General Information Comment Organism
additional information lipid and ceramide content analysis in untreated and inhibitor-treated ARPE-19 cells, overview Homo sapiens