Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SKI II | noncompetitive inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II, a dual inhibitor of sphingosine kinases (SKs) 1 and 2, overview. Use of SKI II in the context of cancer therapy | Homo sapiens | |
XM462 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric cancer cell | - |
Homo sapiens | - |
HGC-27 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydroceramide desaturase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Homo sapiens | |
FAD | - |
Homo sapiens | |
NADH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
SKI II | pH 7.4, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | computational ligand docking study and simulations using enzyme structures PDB IDs BC5R and 1IB0, overview | Homo sapiens |
physiological function | dihydroceramide desaturase (Des1), the last enzyme in the de novo synthesis of ceramide (Cer), regulates the balance between dihydroceramides (dhCers) and ceramides | Homo sapiens |