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Literature summary for 1.14.19.17 extracted from

  • Cingolani, F.; Casasampere, M.; Sanllehi, P.; Casas, J.; Bujons, J.; Fabrias, G.
    Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II (2014), J. Lipid Res., 55, 1711-1720 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
SKI II noncompetitive inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II, a dual inhibitor of sphingosine kinases (SKs) 1 and 2, overview. Use of SKI II in the context of cancer therapy Homo sapiens
XM462
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell
-
Homo sapiens
-
HGC-27 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
dihydroceramide desaturase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Homo sapiens
FAD
-
Homo sapiens
NADH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
SKI II pH 7.4, 37°C Homo sapiens

General Information

General Information Comment Organism
additional information computational ligand docking study and simulations using enzyme structures PDB IDs BC5R and 1IB0, overview Homo sapiens
physiological function dihydroceramide desaturase (Des1), the last enzyme in the de novo synthesis of ceramide (Cer), regulates the balance between dihydroceramides (dhCers) and ceramides Homo sapiens