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Literature summary for 1.14.19.1 extracted from

  • Poliakov, E.; Samuel, W.; Duncan, T.; Gutierrez, D.B.; Mata, N.L.; Redmond, T.M.
    Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets beta-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide DELTA4-desaturase 1 (2017), PLoS ONE, 12, e0176487 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
4-oxo-N-(4-hydroxyphenyl)retinamide
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 Homo sapiens
fenretinide i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation. Fenretinide induces degradation of SCD1 in human Rretinal pigment epithelium cells Homo sapiens
additional information no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00767
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-

Source Tissue

Source Tissue Comment Organism Textmining
ARPE-19 cell retinal pigment epithelial cells Homo sapiens
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retinal pigment epithelium cell
-
 Homo sapiens
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Synonyms

Synonyms Comment Organism
SCD1
-
 Homo sapiens
stearoyl-CoA desaturase 1
-
 Homo sapiens

General Information

General Information Comment Organism
additional information lipid and ceramide content analysis in untreated and inhibitor-treated ARPE-19 cells, overview Homo sapiens