BRENDA - Enzyme Database show
show all sequences of 1.14.19.1

X-ray structure of a mammalian stearoyl-CoA desaturase

Bai, Y.; McCoy, J.G.; Levin, E.J.; Sobrado, P.; Rajashankar, K.R.; Fox, B.G.; Zhou, M.; Nature 524, 252-256 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene scd1, recombinant expression of isozyme SCD1 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, which allows growth in media lacking unsaturated fatty acids. Optimization of enzyme expression method; gene scd3, recombinant expression of wild-type and mutant isozymes SCD3 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, wild-type exxpression allows growth in media lacking unsaturated fatty acids
Mus musculus
Crystallization (Commentary)
Crystallization
Organism
purified DELTA2–23 N-terminally truncated recombinant isozyme SCD1 bound to stearoyl-CoA and two ions of Zn2+ instead of Fe2+, X-ray diffraction structure determination and analysis at 2.6 A resolution, single-wavelength anomalous dispersion
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
I112A/E113L
site-directed mutagenesis, the mutation is able to convert isozyme SCD3 from exclusively a 16:0 desaturase into a predominantly 18:0 desaturase
Mus musculus
V119A/D281Q/P282S E113L
site-directed mutagenesis, the mutation of the residues which are located away from the end of the substrate tunnel, causes no change in the reaction specificity of isozyme SCD3
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
an integral membrane enzyme; isozyme SCD1 has four transmembrane helices (TM1-TM4) arranged in a cone-like shape with TM4 sandwiched between TM1 and TM2. Residues in the membrane-spanning region are largely hydrophobic, with the notable exception of a conserved arginine (Arg249) located on TM4 in the center of the cone
Mus musculus
5789
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
a di-iron center in cofactor cytochrome b5; a di-iron center in cofactor cytochrome b5
Mus musculus
Zn2+
incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron. Coordination of both zinc ions is consistent with octahedral geometry with one missing ligand. The nine histidines are highly conserved, and eight of them belong to three histidine-containing motifs (two HXXHH motifs and one HX4H motif in SCD1) that are characteristic of integral membrane desaturases
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
?
-
-
-
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
Mus musculus
-
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
Mus musculus
-
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
P13516
-
-
Mus musculus
Q99PL7
-
-
Purification (Commentary)
Commentary
Organism
recombinant isozyme SCD1 from Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
745883
Mus musculus
?
-
-
-
-
additional information
wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA
745883
Mus musculus
?
-
-
-
-
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
745883
Mus musculus
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
745883
Mus musculus
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
isozyme SCD1 has four transmembrane helices (TM1-TM4) arranged in a cone-like shape with TM4 sandwiched between TM1 and TM2, the N- and C-termini are on the cytosolic side of the membrane. On the cytosolic side, TM2 and TM4 protrude three helical turns out of the membrane and provide some of the coordinating residues for the dimetal active site. The cytosolic domain comprises 93 residues between TM2 and TM3 (C1) and the 90-residue C-terminus (C2). The C1 and C2 domains contain six and five alpha-helices, respectively. Three of the alpha-helices (AH1 on C1 and AH7 and AH9 on C2) are amphipathic and likely provide interactions between the cytosolic domain and the lipid bilayer. Structure analysis and modelling, overview. Structural role of Arg249. Structure of the SCD1 cytoplasmic domain, model
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome b5
regenerates the di-iron center; regenerates the di-iron center
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
gene scd1, recombinant expression of isozyme SCD1 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, which allows growth in media lacking unsaturated fatty acids. Optimization of enzyme expression method
Mus musculus
gene scd3, recombinant expression of wild-type and mutant isozymes SCD3 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, wild-type exxpression allows growth in media lacking unsaturated fatty acids
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome b5
regenerates the di-iron center
Mus musculus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
purified DELTA2–23 N-terminally truncated recombinant isozyme SCD1 bound to stearoyl-CoA and two ions of Zn2+ instead of Fe2+, X-ray diffraction structure determination and analysis at 2.6 A resolution, single-wavelength anomalous dispersion
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
I112A/E113L
site-directed mutagenesis, the mutation is able to convert isozyme SCD3 from exclusively a 16:0 desaturase into a predominantly 18:0 desaturase
Mus musculus
V119A/D281Q/P282S E113L
site-directed mutagenesis, the mutation of the residues which are located away from the end of the substrate tunnel, causes no change in the reaction specificity of isozyme SCD3
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
an integral membrane enzyme
Mus musculus
5789
-
endoplasmic reticulum membrane
isozyme SCD1 has four transmembrane helices (TM1-TM4) arranged in a cone-like shape with TM4 sandwiched between TM1 and TM2. Residues in the membrane-spanning region are largely hydrophobic, with the notable exception of a conserved arginine (Arg249) located on TM4 in the center of the cone
Mus musculus
5789
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
a di-iron center in cofactor cytochrome b5
Mus musculus
Zn2+
incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron. Coordination of both zinc ions is consistent with octahedral geometry with one missing ligand. The nine histidines are highly conserved, and eight of them belong to three histidine-containing motifs (two HXXHH motifs and one HX4H motif in SCD1) that are characteristic of integral membrane desaturases
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
?
-
-
-
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
Mus musculus
-
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
Mus musculus
-
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant isozyme SCD1 from Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
745883
Mus musculus
?
-
-
-
-
additional information
wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA
745883
Mus musculus
?
-
-
-
-
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
745883
Mus musculus
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
745883
Mus musculus
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
isozyme SCD1 has four transmembrane helices (TM1-TM4) arranged in a cone-like shape with TM4 sandwiched between TM1 and TM2, the N- and C-termini are on the cytosolic side of the membrane. On the cytosolic side, TM2 and TM4 protrude three helical turns out of the membrane and provide some of the coordinating residues for the dimetal active site. The cytosolic domain comprises 93 residues between TM2 and TM3 (C1) and the 90-residue C-terminus (C2). The C1 and C2 domains contain six and five alpha-helices, respectively. Three of the alpha-helices (AH1 on C1 and AH7 and AH9 on C2) are amphipathic and likely provide interactions between the cytosolic domain and the lipid bilayer. Structure analysis and modelling, overview. Structural role of Arg249. Structure of the SCD1 cytoplasmic domain, model
Mus musculus
General Information
General Information
Commentary
Organism
evolution
isozymes SCD1 and SCD3 share 89% primary sequence identity, but they yield remarkably different total fatty acid profiles in the recombinant yeast host cells, likely reflecting differences in their preferences for reaction with 16:0 and 18:0 substrates; isozymes SCD1 and SCD3 share 89% primary sequence identity, but they yield remarkably different total fatty acid profiles in the recombinant yeast host cells, likely reflecting differences in their preferences for reaction with 16:0 and 18:0 substrates
Mus musculus
additional information
in SCD3, Ile112, Glu113, Ser292 and Met293 line the distal end of the substrate binding channel, Val119 is near the position of double bond formation, while Asp281 and Pro282 are on the cytoplasmic surface opposite to the CoA binding site; the structure of isozyme SCD1 shows a fold comprising four transmembrane helices capped by a cytosolic domain, and a plausible pathway for lateral substrate access and product egress. The acyl chain of the bound stearoyl-CoA is enclosed in a tunnel buried in the cytosolic domain, and the geometry of the tunnel and configuration of the bound acyl chain provide a structural basis for the regioselectivity and stereospecificity of the desaturation reaction. The dimetal center is coordinated by a unique configuration of nine conserved histidine residues that implies a potentially distinct metal center and mechanism for oxygen activation, isozyme SCD1 structure analysis and modelling, overview. In SCD1, Ala108, Leu109, Ala288 and Val289 line the distal end of the substrate binding channel, Ala115 is near the position of double bond formation, while Gln277 and Ser278 are on the cytoplasmic surface opposite to the CoA binding site. Structural role of Arg249
Mus musculus
physiological function
stearoyl-CoA desaturase (SCD) introduces the first double bond into saturated fatty acyl-CoAs. Since the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters, and triglycerides, SCD is pivotal in fatty acid metabolism; stearoyl-CoA desaturase (SCD) introduces the first double bond into saturated fatty acyl-CoAs. Since the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters, and triglycerides, SCD is pivotal in fatty acid metabolism
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
evolution
isozymes SCD1 and SCD3 share 89% primary sequence identity, but they yield remarkably different total fatty acid profiles in the recombinant yeast host cells, likely reflecting differences in their preferences for reaction with 16:0 and 18:0 substrates
Mus musculus
additional information
in SCD3, Ile112, Glu113, Ser292 and Met293 line the distal end of the substrate binding channel, Val119 is near the position of double bond formation, while Asp281 and Pro282 are on the cytoplasmic surface opposite to the CoA binding site
Mus musculus
additional information
the structure of isozyme SCD1 shows a fold comprising four transmembrane helices capped by a cytosolic domain, and a plausible pathway for lateral substrate access and product egress. The acyl chain of the bound stearoyl-CoA is enclosed in a tunnel buried in the cytosolic domain, and the geometry of the tunnel and configuration of the bound acyl chain provide a structural basis for the regioselectivity and stereospecificity of the desaturation reaction. The dimetal center is coordinated by a unique configuration of nine conserved histidine residues that implies a potentially distinct metal center and mechanism for oxygen activation, isozyme SCD1 structure analysis and modelling, overview. In SCD1, Ala108, Leu109, Ala288 and Val289 line the distal end of the substrate binding channel, Ala115 is near the position of double bond formation, while Gln277 and Ser278 are on the cytoplasmic surface opposite to the CoA binding site. Structural role of Arg249
Mus musculus
physiological function
stearoyl-CoA desaturase (SCD) introduces the first double bond into saturated fatty acyl-CoAs. Since the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters, and triglycerides, SCD is pivotal in fatty acid metabolism
Mus musculus
Other publictions for EC 1.14.19.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744461
Aardema
Stearoyl-CoA desaturase activ ...
Bos taurus
Biol. Reprod.
96
982-992
2017
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-
1
-
-
-
-
-
-
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2
-
2
-
-
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4
-
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2
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1
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1
1
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2
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4
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2
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-
-
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2
2
-
-
-
745482
Ma
Stearoyl-CoA desaturase regul ...
Homo sapiens
J. Hepatol.
67
979-990
2017
-
2
1
-
-
-
1
-
1
-
-
-
-
3
-
-
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5
-
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2
1
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1
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1
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5
-
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-
-
-
-
-
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1
2
2
1
-
-
745785
Yang
Oleic acid stimulation of mot ...
Homo sapiens
Mol. Hum. Reprod.
23
755-770
2017
-
-
1
-
-
-
-
-
-
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1
-
3
-
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3
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1
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1
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1
1
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1
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3
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1
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1
1
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746221
Poliakov
Inhibitory effects of fenreti ...
Homo sapiens
PLoS ONE
12
e0176487
2017
-
-
-
-
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3
-
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2
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2
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1
1
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746542
ALJohani
Insights into stearoyl-CoA de ...
Homo sapiens, Mus musculus
Trends Endocrinol. Metab.
28
831-842
2017
-
2
1
-
1
-
-
-
2
-
-
9
-
6
-
-
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20
-
-
9
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2
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2
1
3
-
2
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6
-
-
9
-
-
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23
-
-
9
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
744416
Koeberle
Stearoyl-CoA desaturase-1 and ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1861
1719-1726
2016
-
2
-
2
-
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3
2
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4
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2
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2
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2
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2
2
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4
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8
8
-
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-
745114
Iwai
Stearoyl-CoA desaturase-1 pro ...
Mus musculus
Int. J. Mol. Sci.
17
E1868
2016
-
1
-
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1
-
-
-
-
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-
1
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2
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2
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1
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1
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1
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1
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1
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1
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2
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1
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4
4
-
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745668
Jung
Characterization of stearoyl- ...
Tigriopus kingsejongensis
Mar. Biotechnol.
18
564-574
2016
-
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1
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1
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2
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3
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1
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1
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1
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2
1
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2
2
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746212
Rodriguez-Cuenca
Stearoyl-CoA desaturase 1 Is ...
Mus musculus
PLoS ONE
11
e0162047
2016
-
-
1
-
1
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-
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1
-
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1
-
1
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4
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1
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1
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1
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1
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1
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4
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1
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2
2
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746444
Chen
Stearoyl-CoA desaturase-1 med ...
Homo sapiens
Sci. Rep.
6
19665
2016
-
-
1
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2
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2
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-
2
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2
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5
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2
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1
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1
1
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2
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2
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2
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5
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2
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3
3
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744487
Sun
Discovery of triazolone deriv ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem.
23
455-465
2015
-
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62
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2
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4
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52
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52
62
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2
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4
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2
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4
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4
4
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745883
Bai
X-ray structure of a mammalia ...
Mus musculus
Nature
524
252-256
2015
-
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1
1
2
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1
2
-
4
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7
-
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1
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5
1
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1
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6
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727153
Yang
4-Bicyclic heteroaryl-piperidi ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
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2014
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727982
Sampath
The role of Stearoyl-CoA desat ...
Mus musculus
J. Biol. Chem.
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2014
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2
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746433
Lyn
Stearoyl-CoA desaturase inhib ...
Homo sapiens
Sci. Rep.
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4549
2014
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1
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2
2
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726658
Stamatikos
Role of stearoyl-CoA desaturas ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
305
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2013
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1
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1
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2
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727148
Matter
Benzimidazole-carboxamides as ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
23
1817-1822
2013
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727151
Yang
4-Bicyclic heteroaryl-piperidi ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
23
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2013
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25
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1
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728632
Takahashi
Macrophage migration inhibitor ...
Homo sapiens
PLoS ONE
8
e78250
2013
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1
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1
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727426
Nashed
Stearoyl-CoA desaturase activi ...
Homo sapiens
Exp. Biol. Med. (Maywood)
237
1007-1017
2012
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-
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1
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5
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5
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1
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1
2
2
1
-
-
727586
Yokoyama
Stearoyl-CoA desaturase 1 (SCD ...
Mus musculus
Gene
497
340-343
2012
-
-
-
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2
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1
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1
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1
1
1
1
-
-
713716
Green
Modulation of palmitate-induce ...
Rattus norvegicus
Am. J. Physiol. Endocrinol. Metab.
300
640-649
2011
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1
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2
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2
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2
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714440
Isabel
Biological activity and precli ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
21
479-483
2011
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22
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4
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22
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22
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-
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-
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726861
Alloatti
Stearoyl-CoA desaturase is an ...
Trypanosoma brucei, Trypanosoma brucei Lister 427
Biochem. Biophys. Res. Commun.
412
286-290
2011
-
-
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1
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10
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-
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1
1
-
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727140
Ramtohul
Bicyclic heteroaryl inhibitors ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
21
5692-5696
2011
-
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-
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43
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4
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2
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41
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41
43
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2
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-
-
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-
-
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696702
Uto
Novel benzoylpiperidine-based ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
20
341-345
2010
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-
-
-
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52
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2
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5
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3
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2
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2
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40
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2
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-
40
52
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2
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-
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3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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712163
Lienard
Elucidation of the sex-pheromo ...
Dendrolimus punctatus
Insect Biochem. Mol. Biol.
40
440-452
2010
-
-
1
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-
-
-
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-
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1
-
9
-
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2
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1
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5
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1
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6
-
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1
-
-
-
-
-
-
-
-
-
-
1
5
-
-
-
714029
Wu
Overexpression of stearoyl-CoA ...
Homo sapiens
Biochem. Biophys. Res. Commun.
398
473-476
2010
-
-
1
-
-
-
-
-
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1
-
-
-
2
-
-
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1
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1
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-
-
-
-
-
-
-
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-
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714406
Ramtohul
SAR and optimization of thiazo ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
20
1593-1597
2010
-
-
-
-
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39
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2
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3
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-
-
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39
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39
39
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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714418
Powell
2-Aryl benzimidazoles: human S ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
20
6366-6369
2010
-
-
-
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51
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2
2
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4
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-
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51
-
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51
51
-
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2
2
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
714663
Igal
Stearoyl-CoA desaturase-1: a n ...
Homo sapiens
Carcinogenesis
31
1509-1515
2010
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
-
-
-
-
5
-
-
-
-
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-
-
-
-
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-
-
-
-
-
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-
-
-
-
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-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
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2
2
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715731
Su
A novel assay of cellular stea ...
Rattus norvegicus
J. Chromatogr. B
878
2427-2432
2010
-
-
-
-
-
-
3
-
-
-
-
-
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2
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-
-
-
-
2
-
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-
-
-
-
-
-
-
-
-
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-
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1
-
-
-
-
-
-
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1
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716200
Turyn
Up-regulation of stearoyl-CoA ...
Rattus norvegicus
Mol. Cell. Biochem.
345
181-188
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
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716406
Tremblay
Stereochemistry of 10-sulfoxid ...
Ricinus communis
Org. Biomol. Chem.
8
1322-1328
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695472
Paton
Biochemical and physiological ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
297
E28-E37
2009
-
-
-
-
-
-
-
-
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1
1
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-
3
-
-
-
-
-
14
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
14
-
-
4
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
696441
Macdonald
Absence of stearoyl-CoA desatu ...
Mus musculus
Biochim. Biophys. Acta
1791
1166-1172
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
696445
Flowers
Stearoyl-CoA desaturase and it ...
Mus musculus
Biochim. Biophys. Acta
1791
85-91
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
696671
Koltun
Novel, potent, selective, and ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
2048-2052
2009
-
-
-
-
-
-
116
-
2
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
-
-
98
-
-
-
2
-
-
-
98
116
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696680
Koltun
Orally bioavailable, liver-sel ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
3050-3053
2009
-
-
-
-
-
-
48
-
2
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
48
-
-
-
-
-
-
-
48
48
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696683
Koltun
Potent, orally bioavailable, l ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
4070-4074
2009
-
-
-
-
-
-
36
-
2
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28
-
-
-
-
-
-
-
28
36
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696684
Uto
Novel and potent inhibitors of ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
19
4151-4158
2009
-
-
-
-
-
-
60
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
51
-
-
-
2
-
-
-
51
60
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696685
Uto
Novel and potent inhibitors of ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
19
4159-4166
2009
-
-
1
-
-
-
42
-
2
-
-
-
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
39
-
-
1
-
-
-
-
39
42
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696690
Li
Thiazole analog as stearoyl-Co ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
5214-5217
2009
-
-
-
-
-
-
10
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
10
10
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697558
Peter
Individual stearoyl-CoA desatu ...
Homo sapiens
Diabetes
58
1757-1765
2009
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
697559
Kotronen
Hepatic stearoyl-CoA desaturas ...
Homo sapiens
Diabetes
58
203-208
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697777
Issandou
Pharmacological inhibition of ...
Homo sapiens, Rattus norvegicus
Eur. J. Pharmacol.
618
28-36
2009
-
-
-
-
-
-
4
-
2
-
-
-
-
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
2
4
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697825
Liu
Stearoyl-CoA desaturase inhibi ...
Homo sapiens, Rattus norvegicus
Expert Opin. Ther. Pat.
19
1169-1191
2009
-
-
-
-
-
-
152
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
16
152
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698917
Sampath
Skin-specific deletion of stea ...
Mus musculus
J. Biol. Chem.
284
19961-19973
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
698977
Li
Hepatic lipid partitioning and ...
Mus musculus
J. Biol. Chem.
284
5637-5644
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
699187
Velliquette
Regulation of human stearoyl-C ...
Homo sapiens
J. Clin. Lipidol.
3
281-288
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
699599
Li
-
Identification and functional ...
Pseudoalteromonas sp., Pseudoalteromonas sp. MLY15
J. Mol. Catal. B
56
96-101
2009
-
-
1
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
699984
Zhou
The association of desaturase ...
Homo sapiens
Metab. Clin. Exp.
58
158-166
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700906
Gratraud
Oleic acid biosynthesis in Pla ...
Plasmodium falciparum
PLoS ONE
4
e6889
2009
-
-
-
-
-
-
4
1
1
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
1
4
-
-
-
2
-
-
-
4
4
-
1
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
701346
Lausada
Effect of cyclosporine and sir ...
Homo sapiens
Transplant. Proc.
41
1865-1870
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684272
Chong
Parallel activation of de novo ...
Homo sapiens
Am. J. Clin. Nutr.
87
817-823
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684339
Dobrzyn
Loss of stearoyl-CoA desaturas ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
294
E357-E364
2008
-
-
-
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
684785
Mar-Heyming
Association of stearoyl-CoA de ...
Homo sapiens
Arterioscler. Thromb. Vasc. Biol.
28
1193-1199
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685606
Xin
Discovery of piperidine-aryl u ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
18
4298-4302
2008
-
-
-
-
-
-
36
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
34
-
-
-
2
-
-
-
34
36
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686320
Stefan
Low hepatic stearoyl-CoA desat ...
Homo sapiens
Diabetologia
51
648-656
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687427
Chang
In vivo inactivation of mycoba ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
190
6686-6696
2008
-
-
1
-
1
-
-
-
2
-
1
4
-
163
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
1
4
-
-
-
-
-
-
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687766
Christianson
Stearoyl-CoA desaturase 2 is r ...
Mus musculus
J. Biol. Chem.
283
2906-2916
2008
1
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688226
Major
Inhibition of stearoyl CoA des ...
Mesocricetus auratus
J. Lipid Res.
49
1456-1465
2008
1
-
-
-
-
-
1
-
-
-
-
1
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688230
Yee
Compartmentalization of stearo ...
Homo sapiens
J. Lipid Res.
49
2124-2134
2008
-
-
-
-
-
-
3
-
-
-
-
3
-
1
-
-
-
-
-
1
1
-
5
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
1
-
-
-
4
3
-
-
-
-
-
3
-
-
-
-
-
1
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688772
Wang
Identification and characteriz ...
Mesocricetus auratus
Lipids
43
197-205
2008
-
-
1
-
-
-
-
-
3
-
1
3
-
9
-
-
1
-
-
5
-
-
6
1
-
-
-
-
-
-
-
1
-
-
-
-
-
3
3
-
-
-
-
-
-
-
9
-
1
3
-
-
-
3
-
11
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689281
Paillard
Plasma palmitoleic acid, a pro ...
Homo sapiens
Nutr. Metab. Cardiovasc. Dis.
18
436-440
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689313
Melhus
A high activity index of stear ...
Homo sapiens
Osteoporos. Int.
19
929-934
2008
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689840
McNamara
The aging human orbitofrontal ...
Homo sapiens
Prostaglandins Leukot. Essent. Fatty Acids
78
293-304
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689882
Goren
Wheat germ cell-free translati ...
Homo sapiens
Protein Expr. Purif.
62
171-178
2008
-
-
1
-
1
-
-
-
2
1
-
1
-
3
-
-
1
-
1
-
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
1
-
1
-
-
-
1
1
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695468
Peter
Induction of stearoyl-CoA desa ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
295
E339-E349
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
695566
Soulard
Development of a high-throughp ...
Rattus norvegicus
Anal. Chim. Acta
627
105-111
2008
-
-
-
-
-
-
2
1
1
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
2
2
-
1
1
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695567
Dillon
Development of a novel LC/MS m ...
Homo sapiens
Anal. Chim. Acta
627
99-104
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697028
Petersson
Serum fatty acid composition a ...
Homo sapiens
Br. J. Nutr.
99
1186-1189
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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1
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1
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2
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1
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1
-
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1
-
-
697181
Chen
Metabolomics reveals that hepa ...
Mus musculus
Cell Metab.
7
135-147
2008
-
-
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3
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1
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-
-
1
1
1
1
-
-
697326
Matouskova
A DELTA9 desaturase from Bombu ...
Bombus lucorum
ChemBioChem
9
2534-2541
2008
-
-
1
-
-
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3
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2
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1
-
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-
-
-
697824
Dobrzyn
-
Inhibition of stearoyI-CoA des ...
Homo sapiens, Rattus norvegicus
Expert Opin. Ther. Pat.
18
457-460
2008
-
-
-
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4
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2
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2
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2
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2
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4
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2
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2
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698511
Taugbol
Cobalt supplied per os reduces ...
Bos taurus
J. Anim. Sci.
86
3062-3068
2008
-
-
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1
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2
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-
699205
Soyeurt
Variation of DELTA9-desaturase ...
Bos taurus
J. Dairy Sci.
91
3211-3224
2008
-
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1
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1
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2
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701423
Reh
Involvement of stearoyl-CoA de ...
Rattus norvegicus, Sus scrofa
Xenobiotica
38
1177-1190
2008
-
-
-
-
-
-
10
-
2
-
2
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4
-
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2
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5
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4
1
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1
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2
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4
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2
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4
10
-
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2
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2
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2
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5
-
-
4
1
-
-
-
1
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-
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-
674215
Chung
Lipogenesis and stearoyl-CoA d ...
Bos taurus
J. Anim. Sci.
85
380-387
2007
-
-
-
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1
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1
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2
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1
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1
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1
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1
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1
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1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
674851
Sampath
Stearoyl-CoA desaturase-1 medi ...
Mus musculus
J. Biol. Chem.
282
2483-2493
2007
-
-
-
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1
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2
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1
1
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1
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-
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-
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-
-
-
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685575
Zhao
Discovery of 1-(4-phenoxypiper ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
3388-3391
2007
-
-
-
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-
37
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1
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1
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1
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1
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36
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1
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36
37
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1
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2
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-
687321
Pavan
Corn oil supplementation to st ...
Bos taurus
J. Anim. Sci.
85
1731-1740
2007
-
-
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1
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3
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10
1
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2
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1
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1
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1
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10
1
-
2
-
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-
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-
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-
-
-
-
688248
Liu
Discovery of potent, selective ...
Homo sapiens, Mus musculus
J. Med. Chem.
50
3086-3100
2007
-
-
-
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42
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2
2
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2
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4
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2
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2
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2
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2
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42
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2
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42
42
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2
2
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2
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2
-
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2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
688607
Toyama
Stearoyl-CoA desaturase activi ...
Rattus norvegicus
J. Pharmacol. Sci.
103
383-390
2007
1
-
1
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1
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3
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3
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2
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1
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1
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1
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2
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3
-
-
3
-
2
-
-
-
2
-
-
-
-
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-
-
-
-
688769
Lengi
Identification and characteriz ...
Bos taurus
Lipids
42
499-508
2007
-
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1
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2
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5
-
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8
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3
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1
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2
2
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2
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14
-
-
3
-
-
-
-
-
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-
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-
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-
-
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672831
Doran
A reduced protein diet induces ...
Sus scrofa
Br. J. Nutr.
95
609-617
2006
-
-
-
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3
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4
1
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4
1
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-
-
-
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-
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-
-
673263
Biddinger
Leptin suppresses stearoyl-CoA ...
Mus musculus
Diabetes
55
2032-2041
2006
-
-
-
-
-
-
-
-
1
-
1
-
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3
-
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1
1
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1
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1
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1
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1
1
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1
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-
-
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-
-
-
-
-
-
-
673285
Dobrzyn
-
Stearoyl-CoA desaturase: a new ...
Mus musculus
Drug Develop. Res.
67
643-650
2006
-
-
1
-
1
-
1
-
-
-
-
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4
-
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7
1
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1
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1
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1
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8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673510
Mainieri
A role for skeletal muscle ste ...
Rattus norvegicus
FASEB J.
20
1751-1753
2006
-
-
-
-
-
-
-
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1
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2
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1
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1
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1
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3
1
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1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
674542
Man
Membrane topology of mouse ste ...
Mus musculus
J. Biol. Chem.
281
1251-1260
2006
-
-
1
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7
-
-
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2
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1
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3
-
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1
1
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1
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7
-
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2
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1
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-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675062
Flowers
Probing the role of stearoyl-C ...
Mus musculus
J. Clin. Invest.
116
1478-1481
2006
-
-
-
-
-
-
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2
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2
1
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675063
Gutierrez-Juarez
Critical role of stearoyl-CoA ...
Mus musculus, Mus musculus C57/BL6J, Rattus norvegicus
J. Clin. Invest.
116
1686-1695
2006
-
-
-
-
-
-
-
-
-
-
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64
-
-
-
-
-
3
2
-
3
-
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-
-
-
-
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-
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-
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3
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675088
Shingfield
Short communication: indigesti ...
Bos taurus
J. Dairy Sci.
89
3006-3010
2006
-
-
-
-
-
-
1
-
-
-
-
-
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3
-
-
-
-
-
1
1
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-
-
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-
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1
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-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675626
Dobrzyn
Stearoyl-CoA desaturase - a ne ...
Mus musculus, Rattus norvegicus, Sus scrofa
J. Physiol. Pharmacol.
57 Suppl 10
31-42
2006
-
-
-
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4
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5
2
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-
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-
-
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-
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-
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5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658480
Hsieh
Stearoyl-CoA desaturase expres ...
Chanos chanos, Ctenopharyngodon idella
Comp. Biochem. Physiol. B
141
95-101
2005
-
-
-
-
-
-
-
-
-
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-
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5
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
659574
Jiang
Prevention of obesity in mice ...
Mus musculus
J. Clin. Invest.
115
1030-1038
2005
-
1
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3
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1
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671701
Wang
Characterization of HSCD5, a n ...
Homo sapiens
Biochem. Biophys. Res. Commun.
332
735-742
2005
-
-
1
-
-
-
-
-
1
-
1
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6
-
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-
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5
1
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2
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2
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2
-
2
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6
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672316
Scaglia
High stearoyl-CoA desaturase p ...
Homo sapiens
Biochim. Biophys. Acta
1687
141-151
2005
-
-
-
-
-
-
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-
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-
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-
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3
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3
1
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1
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3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672976
Hulver
Elevated stearoyl-CoA desatura ...
Homo sapiens
Cell Metab.
2
251-261
2005
-
-
1
-
-
-
-
-
1
-
1
-
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2
-
-
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-
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3
1
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-
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-
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1
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-
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1
-
1
-
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-
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3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673259
Biddinger
Effects of diet and genetic ba ...
Mus musculus
Diabetes
54
1314-1323
2005
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
4
-
1
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-
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1
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-
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2
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673260
Riserus
Rosiglitazone increases indexe ...
Homo sapiens
Diabetes
54
1379-1384
2005
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
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-
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-
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673267
Voss
Gene expression profiling in s ...
Rattus norvegicus
Diabetologia
48
2622-2630
2005
-
-
1
-
-
-
-
-
1
-
-
-
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3
-
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-
-
2
-
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