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Literature summary for 1.14.19.1 extracted from

  • Aardema, H.; van Tol, H.T.A.; Wubbolts, R.W.; Brouwers, J.F.H.M.; Gadella, B.M.; Roelen, B.A.J.
    Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress (2017), Biol. Reprod., 96, 982-992 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Cloned(Commentary)

Cloned (Comment) Organism
gene SCD, quantitative real-time PCR expression analysis Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Bos taurus
-
 palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Bos taurus
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus Q9TT94
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cumulus cell
-
 Bos taurus
-
cumulus-oocyte complex the level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation Bos taurus
-
oocyte low level expression Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Bos taurus palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Bos taurus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD
-
 Bos taurus
SCD1
-
 Bos taurus
stearoyl-CoA desaturase
-
 Bos taurus
stearoyl-CoA desaturase 1
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Bos taurus

General Information

General Information Comment Organism
malfunction chemical SCD1 inhibition in the presence of stearic acid results in a significant induction of apoptosis in cumulus cells of matured cumulus-oocyte complexes. SCD1 inhibition does not affect the levels of palmitic acid and its desaturated form, palmitoleic acid Bos taurus
physiological function cumulus cells can desaturate the potentially toxic stearic acid into oleic acid via stearoyl-CoA desaturase (SCD) activity, cumulus cells protect the oocyte against toxicity by saturated fatty acids. Stearoyl-CoA desaturase 1 activity is related with increased lipid storage in cumulus cells. The level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation Bos taurus