Inhibitors | Comment | Organism | Structure |
---|---|---|---|
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino)acetic acid | - |
Homo sapiens | |
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino)acetic acid | - |
Rattus norvegicus | |
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy)acetic acid | - |
Homo sapiens | |
([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy)acetic acid | - |
Rattus norvegicus | |
2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole | - |
Homo sapiens | |
2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,4,5,9-tetrahydro-6H-purin-6-one | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,4,5,9-tetrahydro-6H-purin-6-one | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-8-ol | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-8-ol | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-b]pyridine | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-b]pyridine | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7-amine | - |
Rattus norvegicus | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[5,4-c]pyridin-4(5H)-one | - |
Homo sapiens | |
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[5,4-c]pyridin-4(5H)-one | - |
Rattus norvegicus | |
3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid | - |
Homo sapiens | |
3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid | - |
Rattus norvegicus | |
5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Homo sapiens | |
5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Rattus norvegicus | |
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Homo sapiens | |
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | - |
Rattus norvegicus | |
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidine | - |
Homo sapiens | |
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidine | - |
Rattus norvegicus | |
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1H-imidazo[4,5-b]pyrazine | - |
Homo sapiens | |
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1H-imidazo[4,5-b]pyrazine | - |
Rattus norvegicus | |
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[4,5-b]pyrazin-2-amine | - |
Homo sapiens | |
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[4,5-b]pyrazin-2-amine | - |
Rattus norvegicus | |
6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-9H-purine | - |
Homo sapiens | |
6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-9H-purine | - |
Rattus norvegicus | |
6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | - |
Homo sapiens | |
6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | - |
Rattus norvegicus | |
8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-6-amine | - |
Homo sapiens | |
8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-6-amine | - |
Rattus norvegicus | |
MF-152 | - |
Homo sapiens | |
MF-152 | - |
Rattus norvegicus | |
[3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | - |
Homo sapiens | |
[3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
SCD | - |
Homo sapiens |
SCD | - |
Rattus norvegicus |
stearoyl-CoA desaturase | - |
Homo sapiens |
stearoyl-CoA desaturase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
pH and temperature not specified in the publication | Homo sapiens | [3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | |
0.000001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [3-(2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl)-1,2,4-oxadiazol-5-yl]methanol | |
0.000001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[4,5-b]pyrazin-2-amine | |
0.000001 | - |
IC50 less than 0.000039 mM, pH and temperature not specified in the publication | Rattus norvegicus | 6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-9H-purine | |
0.000002 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.000003 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1H-imidazo[4,5-b]pyrazine | |
0.000004 | - |
pH and temperature not specified in the publication | Rattus norvegicus | ([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino)acetic acid | |
0.000007 | - |
pH and temperature not specified in the publication | Rattus norvegicus | ([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy)acetic acid | |
0.000007 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.000008 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.00001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | |
0.00001 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | |
0.000016 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.000017 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[4,5-b]pyrazin-2-amine | |
0.000029 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.000038 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-8-ol | |
0.000039 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-6-amine | |
0.000039 | - |
IC50 less than 0.000039 mM, pH and temperature not specified in the publication | Homo sapiens | 6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-9H-purine | |
0.000047 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1H-imidazo[4,5-b]pyrazine | |
0.000048 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | |
0.000053 | - |
pH and temperature not specified in the publication | Homo sapiens | ([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy)acetic acid | |
0.000054 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidine | |
0.000056 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7-amine | |
0.000059 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one | |
0.000083 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-b]pyridine | |
0.000085 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[5,4-c]pyridin-4(5H)-one | |
0.000097 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,4,5,9-tetrahydro-6H-purin-6-one | |
0.000106 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000162 | - |
pH and temperature not specified in the publication | Homo sapiens | 8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-6-amine | |
0.000168 | - |
pH and temperature not specified in the publication | Homo sapiens | ([5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino)acetic acid | |
0.000182 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-d]pyrimidine | |
0.000253 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide | |
0.000257 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purine | |
0.000266 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid | |
0.000268 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[5,4-c]pyridin-4(5H)-one | |
0.000319 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-9H-purin-8-ol | |
0.000378 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,4,5,9-tetrahydro-6H-purin-6-one | |
0.000477 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole | |
0.000755 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl][1,3]thiazolo[4,5-b]pyridine | |
0.01064 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole | |
0.02434 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6,7-dihydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid |