Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.1 extracted from

  • Sampath, H.; Flowers, M.T.; Liu, X.; Paton, C.M.; Sullivan, R.; Chu, K.; Zhao, M.; Ntambi, J.M.
    Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity (2009), J. Biol. Chem., 284, 19961-19973.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
skin
-
 Mus musculus
-
white adipose tissue
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
SCD1
-
 Mus musculus
stearoyl-CoA desaturase-1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function mice with a skin-specific deletion of SCD1 (SKO) have significantly increased energy expenditure, are protected from high fat diet-induced obesity, and display marked sebaceous gland hypoplasia and depletion of sebaceous lipids. SKO mice display severe cold intolerance because of rapid depletion of fuel substrates, including hepatic glycogen, to maintain core body temperature. Unlike mice globally deficient in SCD1, SKO mice have an intact hepatic lipogenic response to acute high carbohydrate feeding Mus musculus