Literature summary for 1.14.19.1 extracted from

Jiang, G.; Li, Z.; Liu, F.; Ellsworth, K.; Dallas-Yang, Q.; Wu, M.; Ronan, J.; Esau, C.; Murphy, C.; Szalkowski, D.; Bergeron, R.; Doebber, T.; Zhang, B.B.
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1 (2005), J. Clin. Invest., 115, 1030-1038.

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Application

Application	Comment	Organism
medicine	treatment with enzyme-specific antisense oligonucleotide inhibitors results in prevention of diet-induced obesity with reductions in the ratio of oleate to stearoyl-CoA in tissues and plasma. Correlation with reduced body adiposity, hepatomegaly and steatosis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	enzyme inhibition by specific antisense oligonucleotide inhibitors, reduction of enzyme expression, reduction of fatty acid synthesis and secretion, increase in fatty acid oxidation	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary culture of hepatocyte	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
SCD1	-	Mus musculus

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Release 2023.1 (January 2023)