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Literature summary for 1.14.18.B1 extracted from

  • Yin, H.; Wu, H.; Zhao, M.; Zhang, Q.; Long, H.; Fu, S.; Lu, Q.
    Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus (2017), Oncotarget, 8, 48938-48947 .
No PubMed abstract available
Search for more literature for 1.14.18.B1

Application

Application Comment Organism
medicine histone demethylase JMJD3 might serve as a therapeutic target for treatment of systemic lupus erythematosus, SLE Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of JMJD3 through the transfection of pcDNA3.1-JMJD3 into healthy donor CD4+ T cells leading to an increase in JMJD3 enrichment, a decrease in H3K27me3 enrichment within the ITGAL (CD11a) promoter, and upregulation of CD11a expression, resulting in T and B cell hyperactivity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information after transfecting the JMJD3 expression plasmid into normal CD4+ T cells isolated from healthy donors, upregulation of JMJD3 binding and the reduction of H3K27me3 enrichment within the CD11a promoter occurs, which increases CD11a expression and enhanced T cell auto-reactivity. In contrast, downregulation of JMJD3 by siRNA-mediated knockdown, reduces JMJD3 binding and increases H3K27me3 enrichment within the CD11a promoter, which suppresses CD11a expression and reverses the auto-reactivity of T cells in systemic lupus erythematosus patients Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15054
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-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte CD4+ cells, expression analysis of enzyme in cells from healthy persons and systemic lupus erythematosus patients: significantly decreased H3K27me3 levels and increased JMJD3 binding are detected within the ITGAL (CD11a) promoter locus in SLE CD4+ T cells compared with those in healthy CD4+ T cells Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
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 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
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 ?

Synonyms

Synonyms Comment Organism
histone demethylase
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 Homo sapiens
JMJD3
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 Homo sapiens

General Information

General Information Comment Organism
physiological function JMJD3, as a histone demethylase, is capable of specifically removing the trimethyl group from the H3K27 lysine residue, triggering target gene activation. Histone demethylase JMJD3 regulates CD11a expression in lupus T cells through changes in histone H3K27 tri-methylation levels in CD4+ T cells of patients with systemic lupus erythematosus by affecting the H3K27me3 levels in the ITGAL (CD11a) promoter region. The monomethylation of H3K27 (H3K27me) is associated with gene activation, whereas H3K27me3 is associated with gene repression Homo sapiens