Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.18.B1 extracted from

  • Xia, M.; Yao, L.; Zhang, Q.; Wang, F.; Mei, H.; Guo, X.; Huang, W.
    Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3 (2017), Oncotarget, 8, 19795-19802 .
No PubMed abstract available
Search for more literature for 1.14.18.B1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15054
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
renal cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone H3K27 demethylase
-
 Homo sapiens
JMJD3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of histone H3K27 demethylase JMJD3 by long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, a kind of non-protein coding transcripts longer than 200 nucleotides. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci. HOTAIR can affect histone H3K27 methylation and its target genes' expression up

General Information

General Information Comment Organism
malfunction histone demethylase JMJD3 is reduced and its target gene Snai1 expression is downregulated after HOTAIR suppression. The cell migration is inhibited in scratch test and transwell assay after HOTAIR knockdown Homo sapiens
physiological function long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, kind of non-protein coding transcripts longer than 200 nucleotides, promotes metastasis of renal cell carcinoma by upregulating histone H3K27 demethylase JMJD3. RNA HOTAIR expression is elevated in tissues of renal cell carcinoma compared to adjacent normal tissues, and positively correlates with metastasis. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci Homo sapiens