BRENDA - Enzyme Database show
show all sequences of 1.14.18.B1

Histone H3K27 demethylase JMJD3 in cooperation with NF-kappaB regulates keratinocyte wound healing

Na, J.; Lee, K.; Na, W.; Shin, J.; Lee, M.; Yune, T.; Lee, H.; Jung, H.; Kim, W.; Ju, B.; J. Invest. Dermatol. 136, 847-858 (2016)
No PubMed abstract available

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
regulation of JMJD3 may provide a therapeutic intervention for treating the chronic skin wounds
Homo sapiens
Cloned(Commentary)
Commentary
Organism
gene KDM6B or JMJD3, quantitative PCR enzyme expression analysis
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O15054
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Homo sapiens
-
keratinocyte
epidermal keratinocytes
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
745509
Homo sapiens
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
-
-
?
Application (protein specific)
Application
Commentary
Organism
medicine
regulation of JMJD3 may provide a therapeutic intervention for treating the chronic skin wounds
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene KDM6B or JMJD3, quantitative PCR enzyme expression analysis
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epidermis
-
Homo sapiens
-
keratinocyte
epidermal keratinocytes
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
745509
Homo sapiens
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
-
-
?
Expression
Organism
Commentary
Expression
Homo sapiens
upregulation of JMJD3 expression in scratch-wounded keratinocytes
up
General Information
General Information
Commentary
Organism
malfunction
inactivation of JMJD3 or NF-kappaB results in aberrant keratinocyte wound healing
Homo sapiens
physiological function
histone H3K27 demethylase JMJD3 is involved in diverse biological processes such as animal development, inflammation, senescence, and apoptosis. Histone H3K27me3 demethylase JMJD3 is involved in keratinocyte differentiation andwound healing. Enzyme JMJD3 upregulation and NF-kappaB activation occur in the region of the wound edge during keratinocyte wound healing. JMJD3 interacts with NF-kappaB, resulting in increased expression of the inflammatory, matrix metalloproteinase, and growth factor genes via demethylation of H3K27me3 at the gene promoters
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
inactivation of JMJD3 or NF-kappaB results in aberrant keratinocyte wound healing
Homo sapiens
physiological function
histone H3K27 demethylase JMJD3 is involved in diverse biological processes such as animal development, inflammation, senescence, and apoptosis. Histone H3K27me3 demethylase JMJD3 is involved in keratinocyte differentiation andwound healing. Enzyme JMJD3 upregulation and NF-kappaB activation occur in the region of the wound edge during keratinocyte wound healing. JMJD3 interacts with NF-kappaB, resulting in increased expression of the inflammatory, matrix metalloproteinase, and growth factor genes via demethylation of H3K27me3 at the gene promoters
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
upregulation of JMJD3 expression in scratch-wounded keratinocytes
up
Other publictions for EC 1.14.18.B1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744413
Maina
Histone demethylase PHF8 regu ...
Homo sapiens
Biochim. Biophys. Acta
1860
1002-1012
2017
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1
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2
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744984
Bao
Inhibition of H3K27me3 histon ...
Danio rerio
Front. Mol. Neurosci.
10
51
2017
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745947
Xia
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Long noncoding RNA HOTAIR pro ...
Homo sapiens
Oncotarget
8
19795-19802
2017
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2
1
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745948
Yin
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Histone demethylase JMJD3 reg ...
Homo sapiens
Oncotarget
8
48938-48947
2017
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1
1
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1
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1
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745509
Na
-
Histone H3K27 demethylase JMJ ...
Homo sapiens
J. Invest. Dermatol.
136
847-858
2016
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1
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