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Literature summary for 1.14.18.6 extracted from
- Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells (2009), J. Lipid Res., 50, 1203-1208.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| RT4-D6P2T cell | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FA2H | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | treatment of D6P2T Schwannoma cells with dibutyryl-cAMP induces exit from the cell cycle with concomitant upregulation of FA2H | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | partial silencing of fatty acid 2-hydroxylase FA2H in D6P2T cells results in 60-70% reduction of hydroxyl fatty acid-dihydroceramide and hydroxyl fatty acid-ceramide, with no effect on nonhydroxy dihydroceramide and ceramide.Under these conditions, dibutyryl-cAMP no longer induces cell cycle exit, and cells continue to grow and divide. FA2H silencing prevents dibutyryl-cAMP-induced upregulation of cyclin-dependent kinase inhibitors p21 and p27 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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