Literature summary for 1.14.18.6 extracted from

Herrero, A.B.; Astudillo, A.M.; Balboa, M.A.; Cuevas, C.; Balsinde, J.; Moreno, S.
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734 (2008), Cancer Res., 68, 9779-9787.

Search for more literature for 1.14.18.6

Application

Application	Comment	Organism
medicine	silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734. Exogenous addition of the 2-hydroxylated fatty acid 2-hydroxy palmitic acid to different human cell lines increases their sensitivity to the cytotoxic compound	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HCT116 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q7L5A8	-	-
Saccharomyces cerevisiae	Q03529	-	-

Synonyms

Synonyms	Comment	Organism
FA2H	-	Homo sapiens
SCS7	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734	Homo sapiens
physiological function	silencing of sphingolipid fatty acyl 2-hydroxylase Scs7 turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Scs7 renders the cells hypersensitive to PM02734	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)