Literature summary for 1.14.18.2 extracted from

Gandolfi, B.; Grahn, R.A.; Gustafson, N.A.; Proverbio, D.; Spada, E.; Adhikari, B.; Cheng, J.; Andrews, G.; Lyons, L.A.; Helps, C.R.
A novel variant in CMAH is associated with blood type AB in Ragdoll cats (2016), PLoS ONE, 11, e0154973 .

Search for more literature for 1.14.18.2

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotyping and genotype-phenotype correlation analysis, genetic variant c.364C>T is highly associated with blood type AB in Ragdoll cats and, to a lesser degree, with type AB in random bred cats, it is associated with the expression of both antigens (N-glycolylneuraminic acid and N-acetylneuraminic acid) on the red blood cell membrane	Felis catus

Cloned (Comment)

Organism

DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotyping and genotype-phenotype correlation analysis, genetic variant c.364C>T is highly associated with blood type AB in Ragdoll cats and, to a lesser degree, with type AB in random bred cats, it is associated with the expression of both antigens (N-glycolylneuraminic acid and N-acetylneuraminic acid) on the red blood cell membrane

Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+	Felis catus	-	CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+	-	Felis catus	CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CMAH	-	Felis catus
CMP-N-acetylneuraminic acid hydroxylase	-	Felis catus

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Felis catus

General Information

General Information	Comment	Organism
evolution	CMAH phylogenetic analysis, genotyping and genotype-phenotype correlation analysis of gene CMAH and blood typa A, B, or AB in cat breeds, overview	Felis catus
malfunction	by inactivating enzyme CMAH, the NeuAc precursor accumulates and NeuGc is absent on the erythrocyte cell surface, thus reducing parasite infection in humans and promoting a positive selection during evolution, which results in the enrichment of resistant blood type antigens	Felis catus
physiological function	cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) is associated with the production of the sialic acids present on cat erythrocytes. CMAH converts N-acetylneuraminic acid (NeuAc) to N-glycolylneuraminic acid (NeuGc) by substituting one of the hydrogen atoms in the methyl moiety with a carboxyl group. A genetic variant of enzyme CMAH is associated with blood type AB in Ragdoll cats	Felis catus