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Literature summary for 1.14.18.11 extracted from

  • Rahier, A.
    Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism (2011), Steroids, 76, 340-352 .
    View publication on PubMed
Search for more literature for 1.14.18.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Nicotiana benthamiana Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
stigmastan-3beta,5alpha,6alpha-triol
-
 Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3alpha,4alpha,5alpha,10alpha,13alpha,20S)-4-methyl-9,19-cycloergosta-7,24(28)-dien-3-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-3-hydroxy-9,19-cycloergosta-7,24(28)-diene-4-carboxylic acid + 6 ferricytochrome b5 + 4 H2O
-
 ir
(3alpha,4alpha,5alpha,10alpha,13alpha,20S)-4-methylcholest-7-en-3-ol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana (3alpha,4alpha,5alpha,10alpha,13alpha,20S)-3-hydroxycholest-7-ene-4-carboxylic acid + 6 ferricytochrome b5 + 4 H2O
-
 ir
24-ethylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana 3beta,4alpha,5alpha-3-hydroxystigmasta-7,24(28)-diene-4-carboxylate + 6 ferricytochrome b5 + 4 H2O
-
 ?
24-methylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+
-
 Arabidopsis thaliana 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + 6 ferricytochrome b5 + 4 H2O
-
 ir

Synonyms

Synonyms Comment Organism
4alpha-methyl-DELTA7-sterol-4alpha-methyl-oxidase
-
 Arabidopsis thaliana
4alpha-methylsterol-4alpha-methyl-oxidase
-
 Arabidopsis thaliana
SMO2
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction when silencing the enzyme, an important accumulation of 4alpha-methyl-DELTA7-sterols is found, with no change in the levels of 4,4-dimethylsterols Arabidopsis thaliana
metabolism the enzyme is involved in the removal of the second C4-methyl group of phytosterol precursors Arabidopsis thaliana