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Literature summary for 1.14.18.1 extracted from

  • Liu, X.; Jia, Y.L.; Chen, J.W.; Liang, G.; Guo, H.Y.; Hu, Y.H.; Shi, Y.; Zhou, H.T.; Chen, Q.X.
    Inhibition effects of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol on the activity of mushroom tyrosinase (2015), J. Biosci. Bioeng., 119, 275-279 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-phenyl-2-butanol a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor fothe monophenoase activity and noncompetitive-type inhibitor for the diphenolase activity Agaricus bisporus
benzylacetone a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor Agaricus bisporus
benzylideneacetone a reversible, potent inhibitor of tyrosinase, mixed-type inhibitor Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-dopa + O2 Agaricus bisporus
-
2 dopaquinone + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-dopa + O2
-
Agaricus bisporus 2 dopaquinone + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
mushroom tyrosinase
-
Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, type, and constants, and inhibition mechanism of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol, overview Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.6
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylacetone
0.8
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus 4-phenyl-2-butanol
1.1
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus 4-phenyl-2-butanol
1.5
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylideneacetone
2
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylideneacetone
2.8
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication Agaricus bisporus benzylacetone

General Information

General Information Comment Organism
additional information tyrosinase is a kind of multiple functional oxidase containing di-copper catalytic core Agaricus bisporus