Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-but-2-enoic acid | non-competitive inhibition | Agaricus bisporus | |
(2E,4E)-hexa-2,4-dienoic acid | non-competitive inhibition | Agaricus bisporus | |
4-chlorosalicylic acid | - |
Agaricus bisporus | |
alpha-cyano-4-hydroxycinnamic acid | - |
Agaricus bisporus | |
azelaic acid | - |
Agaricus bisporus | |
cefazolin | - |
Agaricus bisporus | |
cefodizime | - |
Agaricus bisporus | |
hexanoic acid | mixed-type inhibition | Agaricus bisporus | |
kojic acid | - |
Agaricus bisporus | |
additional information | not inhibited by butyric acid | Agaricus bisporus | |
octanoic acid | mixed-type inhibition | Agaricus bisporus | |
phloridzin dihydrate | - |
Agaricus bisporus | |
tropolone | - |
Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | monophenolase activity | Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-Tyr + O2 | diphenolase activity | Agaricus bisporus | L-Dopa + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.91 | - |
(2E,4E)-hexa-2,4-dienoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
1.54 | - |
octanoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
2.51 | - |
hexanoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | |
12 | - |
(2E)-but-2-enoic acid | in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.9 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E,4E)-hexa-2,4-dienoic acid | |
2.15 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | octanoic acid | |
3.06 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | octanoic acid | |
3.35 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | hexanoic acid | |
4.95 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E,4E)-hexa-2,4-dienoic acid | |
12.05 | - |
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E)-but-2-enoic acid | |
13.2 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | hexanoic acid | |
20 | - |
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C | Agaricus bisporus | (2E)-but-2-enoic acid |
General Information | Comment | Organism |
---|---|---|
physiological function | tyrosinase is a key enzyme in the melanin biosynthesis | Agaricus bisporus |