Application | Comment | Organism |
---|---|---|
drug development | kurarinol has the potential to be further developed as effective and safe anti-browning and skin-whitening agent | Agaricus bisporus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
kurarinol | from the root of Sophora flavescens, shows no antibacterial activity, competitive inhibitor. Is 50times more potent than lavandulylated flavanones sophoraflavanone G and kurarinone | Agaricus bisporus | |
kurarinone | from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor, binds at an allosteric site | Agaricus bisporus | |
sophoraflavanone G | from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-tyrosine + O2 + AH2 | - |
Agaricus bisporus | L-3,4-dihydroxyphenylalanine + H2O + A | - |
? |
Synonyms | Comment | Organism |
---|---|---|
monophenol, polyphenol oxidase | - |
Agaricus bisporus |
tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
enzyme assay at | Agaricus bisporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
enzyme assay at | Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000045 | - |
kurarinol | - |
Agaricus bisporus | |
0.0041 | - |
kurarinone | - |
Agaricus bisporus | |
0.0074 | - |
sophoraflavanone G | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
- |
Agaricus bisporus | kurarinol | |
0.0022 | - |
- |
Agaricus bisporus | kurarinone | |
0.0047 | - |
- |
Agaricus bisporus | sophoraflavanone G |