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Literature summary for 1.14.18.1 extracted from

  • Gao, H.; Nishida, J.; Saito, S.; Kawabata, J.
    Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase (2007), Molecules, 12, 86-97.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxyapigenin 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
6-hydroxygalangin 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
6-hydroxykaempferol 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase. competitive inhibitor Agaricus bisporus
baicalein 5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase Agaricus bisporus
kaempferol
-
Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
copper
-
Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3320
-
-
Agaricus bisporus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopa + 1/2 O2
-
Agaricus bisporus L-dopaquinone + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.148
-
6-hydroxykaempferol a competitive inhibitor of tyrosinase, L-DOPA as a substrate Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.124
-
-
Agaricus bisporus 6-hydroxykaempferol
0.182
-
-
Agaricus bisporus 6-hydroxygalangin
0.193
-
-
Agaricus bisporus 6-hydroxyapigenin
0.262
-
-
Agaricus bisporus kaempferol
0.273
-
-
Agaricus bisporus baicalein