Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | activation of tyrosine hydroxylase activity | Mucuna pruriens |
General Stability | Organism |
---|---|
tyrosine hydroxylation activity is inactivated faster than catecholase activity | Mucuna pruriens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azide | 1 mM, 60% inhibition of catecholase activity | Mucuna pruriens | |
diethyldithiocarbamate | 0.05 mM, 97% inhibition of tyrosinase activity, 83% inhibition of catecholase activity | Mucuna pruriens | |
L-ascorbic acid | - |
Mucuna pruriens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
tyramine | - |
Mucuna pruriens | |
1.09 | - |
dopamine | - |
Mucuna pruriens | |
1.45 | - |
Adrenaline bitartrate | - |
Mucuna pruriens | |
1.8 | - |
L-tyrosine | - |
Mucuna pruriens | |
2 | - |
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | - |
Mucuna pruriens | |
2.5 | - |
alpha-Methyl-dopa | - |
Mucuna pruriens | |
5.55 | - |
D-Dopa | - |
Mucuna pruriens | |
6.66 | - |
L-Dopa | - |
Mucuna pruriens | |
8 | - |
N-Formyl-L-tyrosine | - |
Mucuna pruriens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
2 * 42000, SDS-PAGE | Mucuna pruriens |
90000 | - |
gel filtration | Mucuna pruriens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mucuna pruriens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate, Celite chromatography, DEAE-Sepharose | Mucuna pruriens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Mucuna pruriens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
658 | - |
L-dopa oxidation | Mucuna pruriens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adrenaline bitartrate + O2 | - |
Mucuna pruriens | ? | - |
? | |
alpha-methyl-dopa + O2 | - |
Mucuna pruriens | alpha-methyldopaquinone + H2O | - |
? | |
D-dopa + O2 | - |
Mucuna pruriens | dopaquinone + H2O | - |
r | |
dopa + 1/2 O2 | L-dopa | Mucuna pruriens | dopaquinone + H2O | - |
? | |
dopa + 1/2 O2 | D-dopa | Mucuna pruriens | dopaquinone + H2O | - |
? | |
dopamine + 1/2 O2 | - |
Mucuna pruriens | dopamine quinone + H2O | - |
? | |
L-tyrosine + O2 + AH2 | - |
Mucuna pruriens | L-dopa + H2O + A | - |
? | |
N-formyl-L-tyrosine + O2 | - |
Mucuna pruriens | ? | - |
? | |
noradrenaline + O2 | - |
Mucuna pruriens | ? | - |
? | |
tyramine + O2 | - |
Mucuna pruriens | 4-(2-aminoethyl)cyclohexa-3,5-diene-1,2-dione + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 42000, SDS-PAGE | Mucuna pruriens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 6.5 | catecholase activity | Mucuna pruriens |
7.5 | - |
tyrosine hydroxylase | Mucuna pruriens |