BRENDA - Enzyme Database show
show all sequences of 1.14.17.4

1-Aminocyclopropane-1-carboxylic acid oxidase: insight into cofactor binding from experimental and theoretical studies

Brisson, L.; El Bakkali-Taheri, N.; Giorgi, M.; Fadel, A.; Kaizer, J.; Reglier, M.; Tron, T.; Ajandouz, e.l..H.; Simaan, A.J.; J. Biol. Inorg. Chem. 17, 939-949 (2012)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
bicarbonate
the enzyme requires the presence of CO2 or bicarbonate for activity
Solanum lycopersicum
Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Solanum lycopersicum
Inhibitors
Inhibitors
Commentary
Organism
Structure
(1-amino-1-methyl)ethylphosphonic acid
competitive inhibitor versus both 1-aminocyclopropane-1-carboxylate and bicarbonate
Solanum lycopersicum
1-aminocyclopropane-1-phosphonic acid
competitive inhibitor versus both 1-aminocyclopropane-1-carboxylate and bicarbonate
Solanum lycopersicum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
1-aminocyclopropane-1-carboxylate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
2.7
-
ascorbate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
a nonheme Fe(II)-containing enzyme
Solanum lycopersicum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-aminocyclopropane-1-carboxylate + ascorbate + O2 + H+
Solanum lycopersicum
-
ethylene + cyanide + dehydroascorbate + CO2 + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Solanum lycopersicum
-
-
-
Purification (Commentary)
Commentary
Organism
DEAE Sepharose resin column chromatography
Solanum lycopersicum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-aminocyclopropane-1-carboxylate + ascorbate + O2 + H+
-
727997
Solanum lycopersicum
ethylene + cyanide + dehydroascorbate + CO2 + H2O
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.19
-
1-aminocyclopropane-1-carboxylate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
0.2
-
ascorbate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
Cofactor
Cofactor
Commentary
Organism
Structure
ascorbate
-
Solanum lycopersicum
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.5
-
1-aminocyclopropane-1-phosphonic acid
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
2.3
-
(1-amino-1-methyl)ethylphosphonic acid
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
bicarbonate
the enzyme requires the presence of CO2 or bicarbonate for activity
Solanum lycopersicum
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Solanum lycopersicum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ascorbate
-
Solanum lycopersicum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(1-amino-1-methyl)ethylphosphonic acid
competitive inhibitor versus both 1-aminocyclopropane-1-carboxylate and bicarbonate
Solanum lycopersicum
1-aminocyclopropane-1-phosphonic acid
competitive inhibitor versus both 1-aminocyclopropane-1-carboxylate and bicarbonate
Solanum lycopersicum
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.5
-
1-aminocyclopropane-1-phosphonic acid
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
2.3
-
(1-amino-1-methyl)ethylphosphonic acid
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
1-aminocyclopropane-1-carboxylate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
2.7
-
ascorbate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
a nonheme Fe(II)-containing enzyme
Solanum lycopersicum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-aminocyclopropane-1-carboxylate + ascorbate + O2 + H+
Solanum lycopersicum
-
ethylene + cyanide + dehydroascorbate + CO2 + H2O
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE Sepharose resin column chromatography
Solanum lycopersicum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-aminocyclopropane-1-carboxylate + ascorbate + O2 + H+
-
727997
Solanum lycopersicum
ethylene + cyanide + dehydroascorbate + CO2 + H2O
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.19
-
1-aminocyclopropane-1-carboxylate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
0.2
-
ascorbate
in 50 mM MOPS, pH 7.0, at 29C
Solanum lycopersicum
Other publictions for EC 1.14.17.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745005
Chersicola
1-Aminocyclopropane-1-carboxy ...
Solanum lycopersicum
Front. Plant Sci.
8
464
2017
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1
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2
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2
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5
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9
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14
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2
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2
4
-
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745036
Xiao
Cloning and expression of the ...
Agrostis stolonifera
Genet. Mol. Res.
15
0000
2016
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1
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3
1
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1
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3
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1
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1
1
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1
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2
2
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746110
Datta
Glutathione regulates 1-amino ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Plant Physiol.
169
2963-2981
2015
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1
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1
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4
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3
3
3
3
-
-
727091
Meng
Identification and active site ...
Agaricus bisporus
Biochim. Biophys. Acta
1840
120-128
2014
1
-
1
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6
-
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1
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1
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3
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6
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745625
Kosugi
-
2-Aminooxyisobutyric acid inh ...
Dianthus caryophyllus
J. Plant Biol.
57
218-224
2014
-
1
1
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1
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1
1
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745818
Sekeli
-
RNA interference of 1-aminocy ...
Carica papaya
Molecules
19
8350-8362
2014
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1
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1
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1
2
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726692
Dilley
1-Aminocyclopropane-1-carboxyl ...
Malus domestica
AoB plants
5
plt031
2013
3
-
1
-
53
-
1
31
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1
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31
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2
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1
1
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744060
Dilley
1-Aminocyclopropane-1-carboxy ...
Malus domestica
AoB Plants
5
plt03
2013
4
-
1
-
53
-
1
31
-
1
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1
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3
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1
1
1
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27
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2
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1
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1
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1
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4
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1
1
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53
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1
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31
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1
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1
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1
1
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27
-
2
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1
-
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1
-
-
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-
3
3
-
-
-
727997
Brisson
1-Aminocyclopropane-1-carboxyl ...
Solanum lycopersicum
J. Biol. Inorg. Chem.
17
939-949
2012
1
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1
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2
2
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1
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1
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2
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1
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1
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2
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1
2
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1
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2
2
2
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1
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1
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1
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1
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2
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728645
Kondo
-
Ethylene production and 1-amin ...
Malus sylvestris
Postharvest Biol. Technol.
72
20-26
2012
-
-
-
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-
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1
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1
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1
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1
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1
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716568
Dorling
Changes in 1-aminocyclopropane ...
Trifolium repens
Plant Physiol. Biochem.
49
1013-1019
2011
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1
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2
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728203
Yu
Methyl jasmonate-induced defen ...
Solanum lycopersicum
J. Plant Physiol.
168
1820-1827
2011
1
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2
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1
4
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716487
Iwamoto
ACO1, a gene for aminocyclopro ...
Oryza sativa
Plant Cell Environ.
33
805-815
2010
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1
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1
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716530
Takahashi
-
Differential expression of ACC ...
Lactuca sativa
Plant Growth Regul.
62
137-149
2010
-
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3
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716629
Huang
Melon EIN3-like transcription ...
Cucumis melo, Cucumis melo cv. Andes
Plant Sci.
178
251-257
2010
-
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690159
Lopez-Gomez
Ripening in papaya fruit is al ...
Carica papaya
Transgenic Res.
18
89-97
2009
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1
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1
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1
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2
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2
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700679
Binnie
Characterization of the 1-amin ...
Malus domestica
Phytochemistry
70
348-360
2009
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1
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3
-
1
2
3
-
5
-
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1
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2
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3
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3
3
2
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3
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3
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3
2
3
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3
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5
-
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3
-
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3
3
3
-
-
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-
700773
Gallie
Tissue-specific expression of ...
Zea mays
Plant Mol. Biol.
69
195-211
2009
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1
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2
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4
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4
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1
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700779
Roeder
SAM levels, gene expression of ...
Nicotiana suaveolens
Plant Mol. Biol.
70
535-546
2009
-
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1
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1
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4
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8
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1
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1
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1
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8
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1
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700917
Kondo
-
Effects of auxin and jasmonate ...
Malus sylvestris
Postharvest Biol. Technol.
51
281-284
2009
1
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1
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1
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2
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1
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1
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684652
Tao
Expression of ethylene-forming ...
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Appl. Microbiol. Biotechnol.
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2008
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689795
Mirica
The nature of O2 activation by ...
Solanum lycopersicum
Proc. Natl. Acad. Sci. USA
105
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2008
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698476
Mirica
18O kinetic isotope effects in ...
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699794
Pan
Isolation of an 1-aminocyclopr ...
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J. Plant Physiol.
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2008
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682365
Lagunes
Effect of exogenous ethylene o ...
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Plant Foods Hum. Nutr.
62
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2007
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682369
Yangkhamman
-
Depression of enzyme activitie ...
Dianthus caryophyllus
Plant Growth Regul.
53
155-162
2007
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684222
Nunez-Palenius
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A single insertion of ACC oxid ...
Cucumis melo
Acta Hortic.
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2007
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684223
Callahan
-
Effects of a peach antisense A ...
Prunus persica
Acta Hortic.
738
567-573
2007
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684224
Hu
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Changes in wound-induced ethyl ...
Cucurbita maxima
Acta Hort.
746
357-361
2007
1
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687313
Kondo
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Effect of jasmonates differed ...
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2007
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689448
Momonoi
-
Cloning and characterization o ...
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Plant Biotechnol.
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2007
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689726
Huang
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Delayed flower senescence of P ...
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Postharvest Biol. Technol.
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2007
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671172
Win
-
An increase in the activity of ...
Citrus aurantiifolia
Acta Hortic.
712
879-884
2006
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675904
Higgins
The Production of Marker-Free ...
Brassica oleracea
Mol. Breed.
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2006
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676538
Chen
Expression of 1-aminocycloprop ...
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Plant Mol. Biol.
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2006
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676720
Hudgins
Ethylene in induced conifer de ...
Picea glauca, Picea sitchensis, Pseudotsuga menziesii
Planta
224
865-877
2006
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658989
Tierney
ENDOR studies of the ligation ...
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J. Am. Chem. Soc.
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2005
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659653
Zheng
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Extraction and characterizatio ...
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J. Jpn. Soc. Hort. Sci.
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159-166
2005
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671170
Woltering
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Regulation and role of differe ...
Antirrhinum majus, Antirrhinum majus L.
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213-218
2005
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673814
Gapper
Senescence-associated down-reg ...
Brassica oleracea
Funct. Plant Biol.
32
891-901
2005
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Murti
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Effects of paclobutrazol on le ...
Mangifera indica
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32
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2005
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657839
Seo
The active site and substrate- ...
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Biochem. J.
380
339-346
2004
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658424
Zhang
Crystal structure and mechanis ...
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Chem. Biol.
11
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2004
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659526
Rocklin
Mechanistic studies of 1-amino ...
Persea americana
J. Biol. Inorg. Chem.
9
171-182
2004
1
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660076
Rodriguez-Gacio
The final step of the ethylene ...
Brassica rapa
Physiol. Plant.
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132-140
2004
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1
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1
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659995
Scott
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Cloning of the full-length ACC ...
Trifolium repens
NATO Sci. Ser. Ser. I
349
76-77
2003
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639310
Charng
The catalytic mechanism of 1-a ...
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Arch. Biochem. Biophys.
385
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2001
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Thrower
Steady-state kinetics of subst ...
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Biochemistry
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1
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2
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3
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1
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1
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639307
Yu
Differential accumulation of t ...
Vigna radiata
Mol. Cells
8
350-358
1998
2
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1
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3
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2
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639308
Bidonde
Expression and characterizatio ...
Solanum lycopersicum
Eur. J. Biochem.
253
20-26
1998
2
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1
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4
5
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1
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3
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6
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1
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3
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6
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1
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1
1
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6
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3
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12
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6
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3
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3
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3
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3
-
6
-
3
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-
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3
3
-
-
-
-
-
-
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639304
Zhang
Metal-catalyzed oxidation and ...
Solanum lycopersicum
Biochemistry
36
15999-16007
1997
-
-
1
-
13
1
-
8
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1
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1
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2
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1
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2
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1
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4
1
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1
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13
1
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8
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1
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1
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1
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2
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1
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4
1
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-
-
-
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-
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639305
Finlayson
-
Root and leaf specific ACC oxi ...
Helianthus annuus, Zea mays
Phytochemistry
45
869-877
1997
2
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-
-
-
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2
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2
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4
2
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4
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2
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4
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2
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2
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4
2
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4
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2
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4
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639303
Lay
Heterologous expression and si ...
Actinidia deliciosa
Eur. J. Biochem.
242
228-234
1996
-
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1
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7
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1
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3
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1
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2
4
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2
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1
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7
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1
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1
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2
4
-
2
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-
-
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-
-
-
-
-
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639301
Zhang
-
Expression, purification and c ...
Solanum lycopersicum
Biochem. J.
307
77-85
1995
6
-
1
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1
5
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1
1
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1
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1
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1
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6
-
1
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1
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6
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1
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1
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5
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1
1
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1
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1
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6
-
1
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1
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-
-
-
-
-
-
-
-
639302
Mizutani
-
Effect of pH on CO2-activated ...
Malus domestica
Phytochemistry
39
751-755
1995
2
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-
-
-
-
-
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1
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1
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1
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3
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1
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1
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2
-
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3
-
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-
-
-
-
-
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639300
Finlayson
-
Influence of CO2 on ACC oxidas ...
Helianthus annuus
Phytochemistry
35
847-851
1994
4
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1
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1
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1
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1
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2
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2
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1
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4
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1
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1
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1
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2
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2
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1
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2
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-
-
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-
-
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-
639312
Vioque
-
Extraction and biochemical cha ...
Pyrus communis
Physiol. Plant.
90
334-338
1994
4
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-
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2
1
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1
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1
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1
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1
2
3
4
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2
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1
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4
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2
1
1
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1
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1
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1
2
3
4
-
2
-
-
-
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-
-
-
-
-
-
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-
639297
Fernandez-Maculet
Activation of 1-aminocycloprop ...
Malus domestica
Biochem. Biophys. Res. Commun.
193
1168-1173
1993
1
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1
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1
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1
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1
1
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1
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2
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1
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1
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1
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1
1
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3
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1
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2
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639298
Smith
-
Activation of 1-aminocycloprop ...
Cucumis melo
Phytochemistry
32
1381-1386
1993
1
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2
1
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1
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1
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1
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639299
Hyodo
-
Characterization and induction ...
Cucurbita maxima
Plant Cell Physiol.
34
667-671
1993
5
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9
1
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1
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1
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1
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1
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1
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3
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1
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1
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5
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9
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1
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1
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1
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1
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1
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3
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1
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1
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-
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-
-
-
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639296
Dong
Purification and characterizat ...
Malus domestica
Proc. Natl. Acad. Sci. USA
89
9789-9793
1992
4
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1
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2
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1
2
1
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4
-
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1
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2
1
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4
1
1
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1
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4
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1
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2
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1
2
1
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1
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2
1
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4
1
1
-
-
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1
-
-
-
-
-
-
-
-
-
716448
Smith
-
Characterization of the ethyle ...
Cucumis melo
Phytochemistry
31
1485-1494
1992
-
-
-
-
-
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7
1
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1
1
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1
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1
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2
1
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1
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2
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2
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7
-
1
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1
1
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1
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2
1
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1
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