Literature summary for 1.14.17.3 extracted from

Yoo, H.J.; Kim, M.; Kim, M.; Chae, J.S.; Lee, S.H.; Lee, J.H.
The peptidylglycine-alpha-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population (2017), Hum. Genomics, 11, 29 .

Search for more literature for 1.14.17.3

Cloned(Commentary)

Cloned (Comment)	Organism
gene PAM, DNA and amino acid sequence determination and analysis, genotyping	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of naurally occuring single nucleotide polymorphisms (SNPs), including the rs13175330 polymorphism. The presence of the G allele of the gene PAM rs13175330 A>G SNP is associated with a higher risk of hypertension after adjustments for age, sex, BMI, smoking, and drinking. The rs13175330 G allele carriers in the hypertension group treated without antihypertensive therapy (HTN w/o therapy) have significantly higher systolic and diastolic blood pressure than the AA genotype carriers, whereas the G allele carriers in the hypertension group treated with antihypertensive therapy (HTN w/ therapy) show significantly higher diastolic blood pressure. The rs13175330 G allele carriers in the HTN w/o therapy group have significantly increased levels of insulin, insulin resistance, and oxidized low-density lipoprotein (LDL) and significantly decreased LDL-cholesterol levels and LDL particle sizes compared to the AA carriers	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P19021	-	-

Synonyms

Synonyms	Comment	Organism
PAM	-	Homo sapiens
peptidylglycine-alpha-amidating monooxygenase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the rs13175330 polymorphism of the PAM gene is selected from the ten single nucleotide polymorphisms (SNPs) most strongly associated with blood pressure. The presence of the G allele of the PAM rs13175330 A>G SNP is associated with a higher risk of hypertension after adjustments for age, sex, BMI, smoking, and drinking. The PAM rs13175330 A>G SNP is a candidate gene for hypertension in the Korean population. Additionally, the PAM rs13175330 G allele might be associated with insulin resistance and LDL atherogenicity in patients with hypertension. Phenotypes, overview	Homo sapiens
physiological function	peptidylglycine-alpha-amidating monooxygenase (PAM) may play a role in the secretion of atrial natriuretic peptide (ANP), which is a hormone involved in the maintenance of blood pressure. Enzyme PAM is involved in regulation of blood pressure and hypertension	Homo sapiens

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Release 2023.1 (January 2023)