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Literature summary for 1.14.17.3 extracted from
- Looking glass mechanism-based inhibition of peptidylglycine alpha-amidating monooxygenase (2011), Tetrahedron Asymmetry, 22, 283-293.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 cell | Xenopus laevis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid | reversible and irreversible inhibition | Xenopus laevis |  |
| (S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid | reversible and irreversible inhibition | Xenopus laevis | |
| (S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid | reversible and irreversible inhibition | Xenopus laevis | |
| N-acetyl-D-Leu-OCH2COOH | competitive inhibitor | Xenopus laevis | |
| N-acetyl-D-Phe-Gly | - |
Xenopus laevis | |
| N-acetyl-L-Leu-OCH2COOH | competitive inhibitor | Xenopus laevis | |
| N-acetyl-L-Phe-OCH2COOH | competitive inhibitor | Xenopus laevis | |
| O-acetyl-D-mandelyl-Gly | - |
Xenopus laevis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0079 | - |
N-acetyl-L-Phe-Gly | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
| 0.17 | - |
O-acetyl-L-mandelyl-Gly | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| cation-exchange chromatography, anion-exchange chromatography, gel filtration | Xenopus laevis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-Phe-Gly + ascorbate + O2 | - |
Xenopus laevis | N-acetyl-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
| O-acetyl-L-mandelyl-Gly + ascorbate + O2 | - |
Xenopus laevis | O-acetyl-L-mandelyl-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
| peptidylglycine + ascorbate + O2 | - |
Xenopus laevis | peptidyl (S)-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptidylglycine alpha-monooxygenase | - |
Xenopus laevis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0452 | - |
N-acetyl-L-Phe-OCH2COOH | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
| 0.054 | - |
(S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid | pH 6.5, 37°C | Xenopus laevis | |
| 0.057 | - |
(S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid | pH 6.5, 37°C | Xenopus laevis | |
| 0.0598 | - |
N-acetyl-L-Leu-OCH2COOH | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
| 0.06 | - |
(R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid | pH 6.5, 37°C | Xenopus laevis | |
| 1.3 | - |
N-acetyl-D-Phe-Gly | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
| 2.1 | - |
N-acetyl-D-Leu-OCH2COOH | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
| 8.1 | - |
O-acetyl-D-mandelyl-Gly | pH not specified in the publication, temperature not specified in the publication | Xenopus laevis | |
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