Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.17.3 extracted from

  • Prohaska, J.R.; Gybina, A.A.; Broderius, M.; Brokate, B.
    Peptidylglycine-alpha-amidating monooxygenase activity and protein are lower in copper-deficient rats and suckling copper-deficient mice (2005), Arch. Biochem. Biophys., 434, 212-220.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.17.3

Inhibitors

Inhibitors Comment Organism Structure
additional information copper-deficiency decreases the enzyme activity Mus musculus
additional information copper-deficiency decreases the enzyme activity Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
copper dependent on, copper-deficiency decreases the enzyme activity, tissue copper status, overview Mus musculus
copper dependent on, copper-deficiency decreases the enzyme activity, tissue copper status, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is involved in peptide posttranslational activation ?
-
 ?
additional information Rattus norvegicus enzyme is involved in peptide posttranslational activation ?
-
 ?
peptidylglycine + ascorbate + O2 Mus musculus peptidylglycine alpha-hydroxylating monooxygenase reaction peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide ?
peptidylglycine + ascorbate + O2 Rattus norvegicus peptidylglycine alpha-hydroxylating monooxygenase reaction peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 ND4 Swiss Webster mice, suckling copper-deficient mice via copper-deficient diet
-
Rattus norvegicus
-
 Holtzman rats, copper-deficient rats via copper-deficient diet
-

Reaction

Reaction Comment Organism Reaction ID
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O bifunctional enzyme showing peptidylglycine alpha-hydroxylating monooxygenase, EC 1.14.17.3, and peptidylamidoglycolate lyase, PAL, EC 4.3.2.5, activities, the enzyme possesses 2 catalytic domains Mus musculus
a
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O bifunctional enzyme showing peptidylglycine alpha-hydroxylating monooxygenase, EC 1.14.17.3, and peptidylamidoglycolate lyase, PAL, EC 4.3.2.5, activities, the enzyme possesses 2 catalytic domains Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
atrium
-
 Mus musculus
-
atrium
-
 Rattus norvegicus
-
brain
-
 Mus musculus
-
brain midbrain Rattus norvegicus
-
heart
-
 Mus musculus
-
heart
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
additional information enzyme expression level in different tissues in copper adequate and deficient status, overview Mus musculus
-
additional information enzyme expression level in different tissues in copper adequate and deficient status, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in peptide posttranslational activation Mus musculus ?
-
 ?
additional information enzyme is involved in peptide posttranslational activation Rattus norvegicus ?
-
 ?
peptidylglycine + ascorbate + O2 peptidylglycine alpha-hydroxylating monooxygenase reaction Mus musculus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide ?
peptidylglycine + ascorbate + O2 peptidylglycine alpha-hydroxylating monooxygenase reaction Rattus norvegicus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide ?

Synonyms

Synonyms Comment Organism
PAM
-
 Mus musculus
PAM
-
 Rattus norvegicus
peptidylglycine-alpha-amidating monooxygenase
-
 Mus musculus
peptidylglycine-alpha-amidating monooxygenase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
 Mus musculus
ascorbate
-
 Rattus norvegicus