KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
S-decyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.027 | - |
S-(4-nitrobenzyl)-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.032 | - |
S-octyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.035 | - |
leukotriene C4 | pH 6.0, 37°C | Rattus norvegicus | |
0.035 | - |
S-hexyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.067 | - |
S-butyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.1 | - |
N-decanoylglycine | pH 6.0, 37°C | Rattus norvegicus | |
0.11 | - |
S-propyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.13 | - |
glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.22 | - |
D-Tyr-Val-Gly | pH 6.0, 37°C | Rattus norvegicus | |
0.23 | - |
S-ethyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.27 | - |
S-methyl-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
0.42 | - |
N-hexanoylglycine | pH 6.0, 37°C | Rattus norvegicus | |
1.1 | - |
S-(1,2-dicarboxyethyl)-glutathione | pH 6.0, 37°C | Rattus norvegicus | |
2.1 | - |
gamma-Glu-Gly-Gly | pH 6.0, 37°C | Rattus norvegicus | |
9.3 | - |
N-acetylglycine | pH 6.0, 37°C | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | bifunctional copper- and zinc-dependent enzyme | Rattus norvegicus | |
Zn2+ | bifunctional copper- and zinc-dependent enzyme | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + ascorbate + O2 | Rattus norvegicus | - |
gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
additional information | Rattus norvegicus | cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones, inhibition of the enzyme leads to a decrease in alpha-aminated peptide production and accumulation of glycine-extended precursors | ? | - |
? | |
R-CO-NH-CH2-COOH + ascorbate + O2 | Rattus norvegicus | - |
R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
bifunctional copper- and zinc-dependent enzyme | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
medullary thyroid carcinoma cell | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
3 | - |
purified recombinant enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Tyr-Val-Gly + ascorbate + O2 | - |
Rattus norvegicus | D-Tyr-Val-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
gamma-Glu-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | gamma-Glu-Gly-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
glutathione + ascorbate + O2 | - |
Rattus norvegicus | gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
leukotriene C4 + ascorbate + O2 | - |
Rattus norvegicus | ? + dehydroascorbate + H2O | - |
? | |
additional information | cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones, inhibition of the enzyme leads to a decrease in alpha-aminated peptide production and accumulation of glycine-extended precursors | Rattus norvegicus | ? | - |
? | |
additional information | substrate specificity, cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones | Rattus norvegicus | ? | - |
? | |
N-acetylglycine + ascorbate + O2 | - |
Rattus norvegicus | acetylamine + glyoxylate + dehydroascorbate + H2O | - |
? | |
N-decanoylglycine + ascorbate + O2 | - |
Rattus norvegicus | decanoylamine + glyoxylate + dehydroascorbate + H2O | - |
? | |
N-hexanoylglycine + ascorbate + O2 | - |
Rattus norvegicus | hexanoylamine + glyoxylate + dehydroascorbate + H2O | - |
? | |
R-CO-NH-CH2-COOH + ascorbate + O2 | - |
Rattus norvegicus | R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O | - |
? | |
R-CO-NH-CH2-COOH + ascorbate + O2 | via hydroxylated reaction intermediates | Rattus norvegicus | R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O | - |
? | |
S-(1,2-dicarboxyethyl)-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-(1,2-dicarboxyethyl)-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-(4-nitrobenzyl)-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-(4-nitrobenzyl)-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-butyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-butyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-decyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-decyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-ethyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-ethyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-hexyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-hexyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-methyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-methyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-octyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-octyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? | |
S-propyl-glutathione + ascorbate + O2 | - |
Rattus norvegicus | S-propyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAM | - |
Rattus norvegicus |
peptidylglycine alpha-amidating monooxygenase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Rattus norvegicus |