Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Disulfiram | pharmaceutical inhibition of enzyme DBH | Penaeus vannamei |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | enzyme-bound, required for activity | Penaeus vannamei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dopamine + ascorbate + O2 | Penaeus vannamei | - |
noradrenaline + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penaeus vannamei | A0A1I9LDK0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hemocyte | - |
Penaeus vannamei | - |
hepatopancreas | - |
Penaeus vannamei | - |
thoracic ganglion | - |
Penaeus vannamei | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dopamine + ascorbate + O2 | - |
Penaeus vannamei | noradrenaline + dehydroascorbate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DBH | - |
Penaeus vannamei |
dopamine beta-hydroxylase | - |
Penaeus vannamei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Penaeus vannamei |
Organism | Comment | Expression |
---|---|---|
Penaeus vannamei | enzyme downregulation by LvDBH-dsRNA | down |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the copper type II, ascorbate-dependent monooxygenases | Penaeus vannamei |
malfunction | enzyme activity and norepinephrine level in shrimps downregulated by LvDBH-dsRNA are reduced, the treated animals show increased susceptibility to Vibrio alginolyticus infection, significantly lower total hemocyte count, phagocytic activity, clearance efficiency, and resistance to Vibrio alginolyticus infection are observed in shrimp that received LvDBH-dsRNA at 3 days post injection compared to those injected with diethyl pyrocarbonate-water or non-targeting gene-dsRNA | Penaeus vannamei |
physiological function | dopamine beta-hydroxylase (DBH) is a copper-containing monooxygenase enzyme that plays an important role in catecholamine synthesis of the neuroendocrine regulatory network. In shrimp, the biosynthesis of catecholamines, including dopamine and norepinephrine, is required for physiological and immunological responses against stress | Penaeus vannamei |