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Literature summary for 1.14.17.1 extracted from

  • Friedman, S.; Kaufman, S.
    3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity (1965), J. Biol. Chem., 240, 4763-4773.
    View publication on PubMed
Search for more literature for 1.14.17.1

Inhibitors

Inhibitors Comment Organism Structure
CO
-
 Bos taurus
diethyldithiocarbamate
-
 Bos taurus
KCN
-
 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a copper protein Bos taurus
Cu2+ enzyme contains a constant amount of Cu2+, 2 mol per mol of protein, and a variable amount of Cu2+, copper content is a linear function of the purity of the enzyme Bos taurus
Fe2+ 0.0004 mM per mol of enzyme Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
290000
-
 sedimentation equilibrium analysis, 5 mM potassium phosphate buffer, pH 6.8, 0.1 M NaCl Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Reaction

Reaction Comment Organism Reaction ID
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.25
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?