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Literature summary for 1.14.16.5 extracted from

  • Watschinger, K.; Keller, M.A.; Golderer, G.; Hermann, M.; Maglione, M.; Sarg, B.; Lindner, H.H.; Hermetter, A.; Werner-Felmayer, G.; Konrat, R.; Hulo, N.; Werner, E.R.
    Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes (2010), Proc. Natl. Acad. Sci. USA, 107, 13672-13677.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cell, expressed in Xenopus laevis oocyte, GFP fusion protein expressed in CHO cell, 6x myc tag version expressed in CHO-K1 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutation of each of 8 conserved His residues (to alanine) which are all essential for activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00258
-
 tetrahydrobiopterin measured in CHO cells after transfection, pH not specified in the publication, 37°C Homo sapiens
0.011
-
 1-O-pyrenedecyl-sn-glycerol measured in CHO cells after transfection, pH not specified in the publication, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
-
 Homo sapiens glycerol + pyrenedecanal + 6,7[8H]-dihydrobiopterin + H2O
-
 ?
alkylglycerol + tetrahydrobiopterin + O2
-
 Homo sapiens glycerol + fatty aldehyde + 6,7[8H]-dihydrobiopterin + H2O after rapid decay of the resulting unstable primary product (hemiacetal) ?

Synonyms

Synonyms Comment Organism
alkylglycerol monooxygenase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00139
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 1,10-phenanthroline