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Literature summary for 1.14.16.4 extracted from
- Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability (2008), Neuroscience, 155, 485-491.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene TPH2, cloning of four haplotypes of TPH2 into pcDNA3.1 and stable transfected into rat PC-12 cells, transient expressionin HEK-293 cells, quantitative real-time PCR expression analysis and comparison of mRNA stabilities, overview | Macaca mulatta |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | C74A and G223A are naturally occuring, nonsynonymous single nucleotide polymorphisms | Macaca mulatta |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, about, recombinant enzyme, SDS-PAGE | Macaca mulatta |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | Macaca mulatta | the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca mulatta | Q2HZ26 | - |
- |
| no activity in Rattus norvegicus | - |
PC-12 cells | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | - |
Macaca mulatta | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders | Macaca mulatta | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50000, about, recombinant enzyme, SDS-PAGE | Macaca mulatta |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPH2 | - |
Macaca mulatta |
| tryptophan hydroxylase-2 | - |
Macaca mulatta |
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Release 2023.1 (January 2023)
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