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Literature summary for 1.14.16.4 extracted from

  • Clark, J.A.; Flick, R.B.; Pai, L.Y.; Szalayova, I.; Key, S.; Conley, R.K.; Deutch, A.Y.; Hutson, P.H.; Mezey, E.
    Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice (2008), Mol. Psychiatry, 13, 498-506.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of TPH2 in COS cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 Homo sapiens
additional information glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 Mus musculus
additional information glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
x * 47000, recombinant enzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Mus musculus the enzyme is responsible for serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens the enzyme is responsible for serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus the enzyme is responsible for serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 Mus musculus C57BL/6 the enzyme is responsible for serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9
-
-
Mus musculus
-
C57/BL6 mice
-
Mus musculus C57BL/6
-
C57/BL6 mice
-
Rattus norvegicus Q8CGU9 female Spargue-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain in raphe nuclei, in lateral hypothalamic nuclei and in pineal body Mus musculus
-
brain in raphe nuclei, in lateral hypothalamic nuclei and in pineal body Homo sapiens
-
brain in raphe nuclei, in lateral hypothalamic nuclei and in pineal body Rattus norvegicus
-
frontal cortex
-
Mus musculus
-
frontal cortex
-
Homo sapiens
-
frontal cortex
-
Rattus norvegicus
-
hypothalamus
-
Mus musculus
-
hypothalamus
-
Homo sapiens
-
hypothalamus
-
Rattus norvegicus
-
additional information analysis of TPH2 expression in brain tissues, overview Mus musculus
-
additional information analysis of TPH2 expression in brain tissues, overview Homo sapiens
-
additional information analysis of TPH2 expression in brain tissues, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2
-
Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is responsible for serotonin biosynthesis Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is responsible for serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is responsible for serotonin biosynthesis Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2
-
Mus musculus C57BL/6 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is responsible for serotonin biosynthesis Mus musculus C57BL/6 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Subunits

Subunits Comment Organism
? x * 47000, recombinant enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
TPH2
-
Mus musculus
TPH2
-
Homo sapiens
TPH2
-
Rattus norvegicus
tryptophan hydroxylase-2
-
Mus musculus
tryptophan hydroxylase-2
-
Homo sapiens
tryptophan hydroxylase-2
-
Rattus norvegicus