Cloned (Comment) | Organism |
---|---|
expression of TPH2 in COS cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 | Homo sapiens | |
additional information | glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 | Mus musculus | |
additional information | glucocorticoids inhibits TPH2 expression, the suppression is blocked by mifepristone, i.e. RU-486 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47000 | - |
x * 47000, recombinant enzyme, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | the enzyme is responsible for serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | the enzyme is responsible for serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | the enzyme is responsible for serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus C57BL/6 | the enzyme is responsible for serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | - |
- |
Mus musculus | - |
C57/BL6 mice | - |
Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Rattus norvegicus | Q8CGU9 | female Spargue-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in raphe nuclei, in lateral hypothalamic nuclei and in pineal body | Mus musculus | - |
brain | in raphe nuclei, in lateral hypothalamic nuclei and in pineal body | Homo sapiens | - |
brain | in raphe nuclei, in lateral hypothalamic nuclei and in pineal body | Rattus norvegicus | - |
frontal cortex | - |
Mus musculus | - |
frontal cortex | - |
Homo sapiens | - |
frontal cortex | - |
Rattus norvegicus | - |
hypothalamus | - |
Mus musculus | - |
hypothalamus | - |
Homo sapiens | - |
hypothalamus | - |
Rattus norvegicus | - |
additional information | analysis of TPH2 expression in brain tissues, overview | Mus musculus | - |
additional information | analysis of TPH2 expression in brain tissues, overview | Homo sapiens | - |
additional information | analysis of TPH2 expression in brain tissues, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is responsible for serotonin biosynthesis | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is responsible for serotonin biosynthesis | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is responsible for serotonin biosynthesis | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus C57BL/6 | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is responsible for serotonin biosynthesis | Mus musculus C57BL/6 | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 47000, recombinant enzyme, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Mus musculus |
TPH2 | - |
Homo sapiens |
TPH2 | - |
Rattus norvegicus |
tryptophan hydroxylase-2 | - |
Mus musculus |
tryptophan hydroxylase-2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Rattus norvegicus |