Cloned (Comment) | Organism |
---|---|
expression of isozymes TPH1 and TPH2 in Escherichia coli | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Tph1 homozygous null mice from a 129S5/SvEvBrd and C57BL/6J hybrid background | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LP-533401 | - |
Mus musculus | |
LP-615819 | - |
Mus musculus | |
additional information | development and pharmacokinetic and pharmacodynamic effects of inhibitors inhibiting specifically the enzyme in the gastrointestinal tract, inhibitory potency on different genotypes, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | first and rate-limiting step in serotonin biosynthesis, serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal sensation, secretion, and motility | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes TPH1 and TPH2 | - |
Purification (Comment) | Organism |
---|---|
recombinant isozymes TPH1 and TPH2 from Escherichia coli by pterin affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
gastrointestinal tract | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | first and rate-limiting step in serotonin biosynthesis, serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal sensation, secretion, and motility | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH1 | - |
Mus musculus |
TPH2 | - |
Mus musculus |
tryptophan hydroxylase | - |
Mus musculus |