Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenylalanine | - |
Mus musculus | |
3-amino-3-[4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenyl]propanoic acid | - |
Mus musculus | |
3-[1-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)piperidin-4-yl]alanine | - |
Mus musculus | |
3-[3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-1H-pyrazol-1-yl]alanine | - |
Mus musculus | |
3-[5-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)pyridin-2-yl]alanine | - |
Mus musculus | |
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-2-fluorophenylalanine | - |
Mus musculus | |
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-a-methylphenylalanine | - |
Mus musculus | |
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-(5-[[(1-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-(5-[[(1-hydroxynaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-(5-[[(2'-methylbiphenyl-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-(5-[[(9-ethyl-9H-carbazol-3-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-(5-[[3-(cyclopentyloxy)-4-methoxybenzyl]amino]pyrazin-2-yl)-L-phenylalanine | - |
Mus musculus | |
4-Chlorophenylalanine | - |
Mus musculus | |
4-ethynylphenylalanine | - |
Mus musculus | |
4-[4-amino-6-(1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[4-amino-6-(2,2,2-trifluoro-1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[4-amino-6-(2,2,2-trifluoro-1-[2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]ethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[4-amino-6-[2,2,2-trifluoro-1-(2-furan-2-ylphenyl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[4-amino-6-[2,2,2-trifluoro-1-(3'-methylbiphenyl-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[4-amino-6-[2,2,2-trifluoro-1-(5-furan-2-ylthiophen-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(3,4-dimethoxybenzyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(4-cyanobenzyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(biphenyl-4-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(cyclohexylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(furan-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(pyridin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus | |
4-[5-[(quinolin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | first and rate-limiting step in serotonin biosynthesis, overview. Serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter that modulates central and peripheral functions through action on neurons, smooth muscle, and other cell types | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
central nervous system | - |
Mus musculus | - |
additional information | TPH1 is primarily expressed in the pineal gland and non-neuronal tissues, such as enterochromaffin cells of the gastrointestinal tract. TPH2, the dominant isozyme in the brain, is expressed exclusively in neuronal cells, such as dorsal raphe or myenteric plexus cells | Mus musculus | - |
pineal gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | first and rate-limiting step in serotonin biosynthesis, overview. Serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter that modulates central and peripheral functions through action on neurons, smooth muscle, and other cell types | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH1 | - |
Mus musculus |
TPH2 | - |
Mus musculus |
tryptophan hydroxylase | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000013 | - |
- |
Mus musculus | 4-(5-[[(1-hydroxynaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | |
0.000024 | - |
- |
Mus musculus | 4-[4-amino-6-[2,2,2-trifluoro-1-(2-furan-2-ylphenyl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.000026 | - |
- |
Mus musculus | 4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine | |
0.000029 | - |
- |
Mus musculus | 4-[4-amino-6-(2,2,2-trifluoro-1-[2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]ethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.000031 | - |
- |
Mus musculus | 4-(5-[[(9-ethyl-9H-carbazol-3-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | |
0.000032 | - |
- |
Mus musculus | 4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine | |
0.00004 | - |
- |
Mus musculus | 4-(5-[[(2'-methylbiphenyl-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | |
0.000044 | - |
- |
Mus musculus | 4-[5-[(biphenyl-4-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.000045 | - |
- |
Mus musculus | 4-(5-[[3-(cyclopentyloxy)-4-methoxybenzyl]amino]pyrazin-2-yl)-L-phenylalanine | |
0.000046 | - |
- |
Mus musculus | 4-(5-[[(1-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine | |
0.000054 | - |
- |
Mus musculus | 4-[4-amino-6-[2,2,2-trifluoro-1-(5-furan-2-ylthiophen-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.000069 | - |
- |
Mus musculus | 4-[5-[(3,4-dimethoxybenzyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.00007 | - |
- |
Mus musculus | 4-[4-amino-6-[2,2,2-trifluoro-1-(3'-methylbiphenyl-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.00011 | - |
- |
Mus musculus | 4-[5-[(4-cyanobenzyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.00018 | - |
- |
Mus musculus | 4-[4-amino-6-(2,2,2-trifluoro-1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.00019 | - |
- |
Mus musculus | 4-[5-[(quinolin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.0002 | - |
- |
Mus musculus | 4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-2-fluorophenylalanine | |
0.00024 | - |
- |
Mus musculus | 4-[5-[(cyclohexylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.00038 | - |
- |
Mus musculus | 4-[4-amino-6-(1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine | |
0.00077 | - |
- |
Mus musculus | 3-[1-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)piperidin-4-yl]alanine | |
0.00089 | - |
- |
Mus musculus | 3-[5-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)pyridin-2-yl]alanine | |
0.00096 | - |
- |
Mus musculus | 4-[5-[(furan-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.00377 | - |
- |
Mus musculus | 3-amino-3-[4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenyl]propanoic acid | |
0.00615 | - |
- |
Mus musculus | 4-[5-[(pyridin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine | |
0.011 | - |
- |
Mus musculus | 3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenylalanine | |
0.0111 | - |
- |
Mus musculus | 4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-a-methylphenylalanine | |
0.0126 | - |
- |
Mus musculus | 3-[3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-1H-pyrazol-1-yl]alanine | |
0.03 | - |
- |
Mus musculus | 4-ethynylphenylalanine | |
0.092 | - |
- |
Mus musculus | 4-Chlorophenylalanine |