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Literature summary for 1.14.16.4 extracted from

  • Porter, R.J.; Mulder, R.T.; Joyce, P.R.; Miller, A.L.; Kennedy, M.
    Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression (2008), J. Affect. Disord., 109, 209-212.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene TPH1 genotyping of female and male Caucasian patients with major depression Homo sapiens

Protein Variants

Protein Variants Comment Organism
A218C interaction between gene TPH1 218Ato C or rs1800532 polymorphism and gender in determining plasma TRP whereby presence of the 218C allele, in women, is associated with markedly reduced plasma tryptophan levels, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens low tryptophan levels are associated with depression and may arise because of stress, the hypothalamic and peripheral serotonin, i.e.5-hydroxytryptamine-system has a significant role in appetite regulation, possibly a homeostatic mechanism in regulating peripheral TRP levels, overview 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17752 patients with major depression, gene TPH1
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 low tryptophan levels are associated with depression and may arise because of stress, the hypothalamic and peripheral serotonin, i.e.5-hydroxytryptamine-system has a significant role in appetite regulation, possibly a homeostatic mechanism in regulating peripheral TRP levels, overview Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH1
-
Homo sapiens
tryptophan hydroxylase
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Homo sapiens