Cloned (Comment) | Organism |
---|---|
gene TPH2, DNA and amino acid sequence determination and analysis, genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination and analysis of TPH2 polymorphisms rs10748185, rs2129575, rs1386495, rs1386494, and rs7305115 in terms of genotype, allele, and haplotype-based associations, neither single marker nor haplotype-based analysis shows significant associations between TPH2 and MD, genotyping, in this particular group of stress-induced depression patients TPH1 appears to be more relevant to MD pathogenesis than TPH2, overview | Homo sapiens |
additional information | genotyping, in a particular group of stress-induced depression patients isozyme TPH1 appears to be more relevant to MD pathogenesis than isozyme TPH2, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH2 is rate-limiting in serotonin, i.e. 5-hydroxytryptamine, biosynthesis, serotonin is involved in the pathophysiology of several psychiatric disorders including major depression, MD, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17752 | TPH1; North European Caucasians, healthy persons and major depression patients, isozyme TPH1 | - |
Homo sapiens | Q8IWU9 | North European Caucasians, healthy persons and major depression patients, isozyme TPH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is rate-limiting in serotonin, i.e. 5-hydroxytryptamine, biosynthesis, serotonin is involved in the pathophysiology of several psychiatric disorders including major depression, MD, overview | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH-1 | - |
Homo sapiens |
TPH-2 | - |
Homo sapiens |
tryptophan hydroxylase 1 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |