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Literature summary for 1.14.16.4 extracted from

  • Canli, T.; Congdon, E.; Todd Constable, R.; Lesch, K.P.
    Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing (2008), Biol. Psychol., 79, 118-125.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
gene TPH2, DNA and amino acid sequence determination and analysis of wild-type and mutant genes, genotyping, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, isolation and analysis of a serotonergic gene polymorphism related to brain affective processing is the tryptophan hydroxylase-2 gene TPH2, TPH2 rs4570625 genotyping, behavioural phenotypes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH2 is the rate-limiting enzyme during 5-hydroxytryptamine synthesis in the brain 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information Homo sapiens additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, serotonergic regulation of neural processing of affective stimuli with the striatum as a critical site where gene-gene regulation takes place, whole brain analysis for emotional word Stroop task, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9 gene TPH2
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
striatum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme during 5-hydroxytryptamine synthesis in the brain Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, serotonergic regulation of neural processing of affective stimuli with the striatum as a critical site where gene-gene regulation takes place, whole brain analysis for emotional word Stroop task, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH2
-
 Homo sapiens
tryptophan hydroxylase-2
-
 Homo sapiens