Literature summary for 1.14.16.4 extracted from

Reuter, M.; Esslinger, C.; Montag, C.; Lis, S.; Gallhofer, B.; Kirsch, P.
A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: A genetic imaging study (2008), Biol. Psychol., 79, 111-117.

Search for more literature for 1.14.16.4

Protein Variants

Protein Variants	Comment	Organism
additional information	the naturally occuring functional promoter polymorphism TPH2-703 G/T of the tryptophan hydroxylase 2 gene is involved in prefrontal and parietal regions are activated during working memory tasks, genotype groups of the -703 G/T: a significantly stronger activation of the TT genotype carriers in BA 6, BA 46, and BA 40 is visible in contrast to the GTand GG groups, no significant differences between the genotype groups with respect to age or gender, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Homo sapiens	TPH2 is involved in serotonin biosynthesis, which is involved in behavioural processes, e.g. working memory, overview	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IWU9	Caucasian subjects	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH2 is involved in serotonin biosynthesis, which is involved in behavioural processes, e.g. working memory, overview	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH2	-	Homo sapiens
tryptophan hydroxylase 2	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)