Cloned (Comment) | Organism |
---|---|
TPH2, DNA and amino acid sequence determination and analysis, genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genotyping of TPH2 in depressive patients, the single nucleotide polymorphisms rs4448731 and rs4641527 significantly predict suicide, along with cluster B personality disorders and family history of suicide, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Homo sapiens | TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in major depression disorder, however, may not play a role in impulsive-aggressive behaviors as mediators, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in major depression disorder, however, may not play a role in impulsive-aggressive behaviors as mediators, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Homo sapiens |