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Literature summary for 1.14.16.4 extracted from

  • Wang, L.; Erlandsen, H.; Haavik, J.; Knappskog, P.M.; Stevens, R.C.
    Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neutrotransmitters serotonin and melatonin (2002), Biochemistry, 41, 12569-12574.
    View publication on PubMed
Search for more literature for 1.14.16.4

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method, X-ray crystal structure of a truncated functional form of enzyme (DELTANH102-DELTACOOH402) with the bound cofactor analogue 7,8-dihydro-L-biopterin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-tryptophan substrate inhibition above 0.07 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0078
-
 L-tryptophan doubly truncated enzyme form DELTANH102-DELTACOOH402 Homo sapiens
0.0265
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin doubly truncated enzyme form DELTANH102-DELTACOOH402 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydropteridine + O2 Homo sapiens rate-determining step of serotonin biosynthesis 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17752
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + ?
-
 ?
L-tryptophan + tetrahydropteridine + O2 rate-determining step of serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
TRpOH
-
 Homo sapiens