Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | cell body | Rattus norvegicus | 5737 | - |
endoplasmic reticulum | associated with cell body | Rattus norvegicus | 5783 | - |
Golgi apparatus | associated with cell body | Rattus norvegicus | 5794 | - |
microtubule | dendrites and axons | Rattus norvegicus | 5874 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | Rattus norvegicus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | region of the raphe nucleus of rat midbrain | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.045 | - |
brain tryptophan hydroxylase | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |