Literature summary for 1.14.16.1 extracted from

Becher, I.; Werner, T.; Doce, C.; Zaal, E.A.; Toegel, I.; Khan, C.A.; Rueger, A.; Muelbaier, M.; Salzer, E.; Berkers, C.R.; Fitzpatrick, P.F.; Bantscheff, M.; Savitski, M.M.
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat (2016), Nat. Chem. Biol., 12, 908-910 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
panobinostat	competitive inhibition	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	Rattus norvegicus	-	L-tyrosine + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	-	Rattus norvegicus	L-tyrosine + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
PAH	-	Rattus norvegicus
phenylalanine hydroxylase	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00019	-	at pH 7.0 and 25°C	Rattus norvegicus	panobinostat

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Release 2023.1 (January 2023)