Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-phenylalanine | - |
Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, using 0.1 M Bis-Tris-HCl pH 5.5, 25% (w/v) polyethylene glycol 3350, and 0.2 M magnesium chloride | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
L212P | the mutant shows about 20% activity compared to the wild type enzyme | Homo sapiens |
L249F | the mutant shows about 55% activity compared to the wild type enzyme | Homo sapiens |
L249P | the mutant shows about 5% activity compared to the wild type enzyme | Homo sapiens |
R261P | the mutant shows about 14% activity compared to the wild type enzyme | Homo sapiens |
R270K | active-site mutation | Rattus norvegicus |
R270K | the mutant shows about 15% activity compared to the wild type enzyme | Homo sapiens |
S196Y | the mutant shows about 20% activity compared to the wild type enzyme | Homo sapiens |
T380M | the mutant shows about 25% activity compared to the wild type enzyme | Homo sapiens |
Y204C | the mutant shows wild type activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
210000 | - |
small-angle X-ray scattering | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | Homo sapiens | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00439 | - |
- |
Rattus norvegicus | P04176 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Homo sapiens |
PheH | - |
Rattus norvegicus |
phenylalanine hydroxylase | - |
Homo sapiens |
phenylalanine hydroxylase | - |
Rattus norvegicus |