Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli TB1 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
L-phenylalanine | wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C | Homo sapiens | |
8.3 | - |
(S)-carboxymethyl-L-cysteine | wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C | Homo sapiens | |
20.3 | - |
(S)-methyl-L-cysteine | wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C | Homo sapiens | |
29.8 | - |
N-acetyl-(S)-carboxymethyl-L-cysteine | wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C | Homo sapiens | |
32.1 | - |
N-acetyl-(S)-methyl-L-cysteine | wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00439 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-butyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | ? | - |
? | |
(S)-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | (S)-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O | - |
? | |
(S)-ethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | (S)-ethyl-L-cysteine S-oxide + dihydrobiopterin + H2O | - |
? | |
(S)-ethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | ? | - |
? | |
(S)-methyl-ergothionine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | ? | - |
? | |
(S)-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | (S)-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O | - |
? | |
(S)-propyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | ? | - |
? | |
L-methionine + 5,6,7,8-tetrahydrobiopterin + O2 | low activity | Homo sapiens | ? | - |
? | |
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 | highest activity | Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | thiodiglycolic acid, (S)-pentyl-L-cysteine, (S)-hexyl-L-cysteine, (S)-heptyl-L-cysteine, (S)-octyl-L-cysteine, and (S)-benzyl-L-cysteine are no substrates | Homo sapiens | ? | - |
? | |
N-acetyl-(S)-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | ? | - |
? | |
N-acetyl-(S)-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Homo sapiens |
phenylalanine monooxygenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | - |
Homo sapiens |