Literature summary for 1.14.16.1 extracted from

Zoidakis, J.; Sam, M.; Volner, A.; Han, A.; Vu, K.; Abu-Omar, M.M.
Role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase (2004), J. Biol. Inorg. Chem., 9, 289-296.

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Protein Variants

Protein Variants	Comment	Organism
Y179A	stability and metal binding comparable to wild-type, kcat-value one order of magnitude lower than wild-type, KM-value of L-phenylalanine increases by 10-fold	Chromobacterium violaceum
Y179F	stability and metal binding comparable to wild-type, kcat-value one order of magnitude lower than wild-type	Chromobacterium violaceum

Organism

Organism	UniProt	Comment	Textmining
Chromobacterium violaceum	-	-	-

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Release 2023.1 (January 2023)