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Literature summary for 1.14.16.1 extracted from
- Effect of mutations at Cys237 on the activation state and activity of human phenylalanine hydroxylase (1997), FEBS Lett., 409, 7-11.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity of recombinant enzyme is activated 1.5fold by exposure to pH 8.5-9.0 | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C237D | approx. 3fold higher activity than wild-type | Homo sapiens |
| C237S | approx. 2fold higher activity than wild-type | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | 0.04 | tetrahydrobiopterin | recombinant wild-type, C237S and C237D mutant enzyme | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9.5 | recombinant enzyme, 25% loss of activity at pH 5.5, 15% loss of activity at pH 7.0-8.0 | Homo sapiens |
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