Cloned (Comment) | Organism |
---|---|
coexpression with molecular chaperones GroES/GroEL | Streptomyces coelicolor |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a gene disruption mutant displays no synthesis of both albaflavenone and the albaflavenols, while epi-isozizaene is still produced | Streptomyces coelicolor |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coelicolor | - |
- |
- |
Streptomyces coelicolor A3(2) | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 | - |
Streptomyces coelicolor | (5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O | - |
? | |
(+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 | - |
Streptomyces coelicolor A3(2) | (5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O | - |
? | |
(5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 | - |
Streptomyces coelicolor | albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O | - |
? | |
(5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 | - |
Streptomyces coelicolor A3(2) | albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O | - |
? | |
additional information | enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 | Streptomyces coelicolor | ? | - |
? | |
additional information | enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 | Streptomyces coelicolor A3(2) | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP170A1 | - |
Streptomyces coelicolor |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P-450 | - |
Streptomyces coelicolor |