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Literature summary for 1.14.15.39 extracted from

  • Zhao, B.; Lin, X.; Lei, L.; Lamb, D.C.; Kelly, S.L.; Waterman, M.R.; Cane, D.E.
    Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2) (2008), J. Biol. Chem., 283, 8183-8189.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.15.39

Cloned(Commentary)

Cloned (Comment) Organism
coexpression with molecular chaperones GroES/GroEL Streptomyces coelicolor

Protein Variants

Protein Variants Comment Organism
additional information a gene disruption mutant displays no synthesis of both albaflavenone and the albaflavenols, while epi-isozizaene is still produced Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
-
-
Streptomyces coelicolor A3(2)
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2
-
 Streptomyces coelicolor (5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O
-
 ?
(+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2
-
 Streptomyces coelicolor A3(2) (5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O
-
 ?
(5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2
-
 Streptomyces coelicolor albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O
-
 ?
(5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2
-
 Streptomyces coelicolor A3(2) albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O
-
 ?
additional information enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 Streptomyces coelicolor ?
-
 ?
additional information enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 Streptomyces coelicolor A3(2) ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP170A1
-
 Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450
-
 Streptomyces coelicolor