Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Streptomyces thioluteus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces thioluteus | Q70KH6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7R)-7-hydroxyluteothin + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | - |
Streptomyces thioluteus | aureothin + 2 H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | - |
? | |
luteothin + 2 O2 + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ | - |
Streptomyces thioluteus | aureothin + 3 H2O + 4 oxidized ferredoxin [iron-sulfur] cluster | - |
? | |
luteothin + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ | - |
Streptomyces thioluteus | (7R)-7-hydroxyluteothin + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster | - |
? | |
additional information | the formation of the heterocycle is catalyzed by a single enzyme both in vivo and in vitro. The reaction is a sequential hydroxylation-heterocyclization sequence. The methylene position adjacent to the pyrone ring (C7) is attacked first, which defines the absolute configuration of the resulting heterocycle. The second allylic position (C9a) is then oxygenated by the adjacent hydroxymethyl group | Streptomyces thioluteus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AurH | - |
Streptomyces thioluteus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Streptomyces thioluteus |