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Literature summary for 1.14.15.33 extracted from

  • Xue, Y.; Wilson, D.; Zhao, L.; Liu, H.w.; Sherman, D.H.
    Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae (1998), Chem. Biol., 5, 661-667.
    View publication on PubMed
Search for more literature for 1.14.15.33

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces venezuelae

Organism

Organism UniProt Comment Textmining
Streptomyces venezuelae O87605
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 i.e. YC-17 Streptomyces venezuelae methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Streptomyces venezuelae neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Streptomyces venezuelae pikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

Synonyms Comment Organism
PikC
-
 Streptomyces venezuelae

General Information

General Information Comment Organism
physiological function inactivation of pikC gene abolishes production of all hydroxylated macrolides, with corresponding accumulation of 1-deoxymethymycin and narbomycin in the culture medium Streptomyces venezuelae