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Literature summary for 1.14.15.3 extracted from

  • Fer, M.; Corcos, L.; Dreano, Y.; Plee-Gautier, E.; Salaün, J.; Berthou, F.; Amet, Y.
    Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism (2008), J. Lipid Res., 49, 2379-2389.
    View publication on PubMed
Search for more literature for 1.14.15.3

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,8,11-eicosatrienoic acid + NAD(P)H + H+ + O2
-
 Homo sapiens ? + NAD(P)+ + H2O
-
 ?
arachidonic acid + NAD(P)H + H+ + O2
-
 Homo sapiens (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?
docosahexaenoic acid + NAD(P)H + H+ + O2
-
 Homo sapiens ? + NAD(P)+ + H2O
-
 ?
eicosapentaenoic acid + NAD(P)H + H+ + O2 is less omega-hydroxylated than 5,8,11-eicosatrienoic acid and arachidonic acid Homo sapiens ? + NAD(P)+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP450 omega-hydroxylase
-
 Homo sapiens
CYP4A11
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism CYP4A11 is the least efficient CYP450 omega-hydroxylase in PUFA metabolism. PUFA hydroxylation by CYP4A11 is low and only slightly regiospecific Homo sapiens