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Literature summary for 1.14.15.3 extracted from

  • Hoch, U.; Zhang, Z.; Kroetz, D.L.; Ortiz de Montellano, P.R.
    Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases (2000), Arch. Biochem. Biophys., 373, 63-71.
    View publication on PubMed
Search for more literature for 1.14.15.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli, genes CYP4A1, CYP4A2, CYP4A3 and CYP4A8 Rattus norvegicus
expressed in Escherichia coli, human gene CYP4A11 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonic acid + NADPH + H+ + O2 Homo sapiens
-
 20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
 ?
additional information Homo sapiens 20-hydroxyeicosatetraenoic acid modulates renal transport activities ?
-
 ?
n-alkane + NAD(P)H + H+ + O2 Homo sapiens
-
 n-alkanol + NAD(P)+ + H2O
-
 ?
n-alkane + NAD(P)H + H+ + O2 Rattus norvegicus
-
 n-alkanol + NAD(P)+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
renal cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonic acid + NAD(P)H + H+ + O2
-
 Homo sapiens 20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?
arachidonic acid + NAD(P)H + H+ + O2
-
 Rattus norvegicus 20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?
arachidonic acid + NADPH + H+ + O2
-
 Homo sapiens 20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
 ?
fatty acid + NAD(P)H + H+ + O2 chain length C12-C16, arachidonic acid and oleic acid Homo sapiens omega-hydroxy fatty acid + NAD(P)+ + H2O
-
 ?
fatty acid + NAD(P)H + H+ + O2 chain length C12-C16, arachidonic acid and oleic acid Rattus norvegicus omega-hydroxy fatty acid + NAD(P)+ + H2O
-
 ?
lauric acid + NAD(P)H + H+ + O2
-
 Homo sapiens 12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
 ?
lauric acid + NAD(P)H + H+ + O2
-
 Rattus norvegicus 12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
 ?
additional information 20-hydroxyeicosatetraenoic acid modulates renal transport activities Homo sapiens ?
-
 ?
n-alkane + NAD(P)H + H+ + O2
-
 Homo sapiens n-alkanol + NAD(P)+ + H2O
-
 ?
n-alkane + NAD(P)H + H+ + O2
-
 Rattus norvegicus n-alkanol + NAD(P)+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens