Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.3 extracted from

  • Palmer, C.N.A.; Richardson, T.H.; Griffin, K.J.; Hsu, M.H.; Muerhoff, A.S.; Clark, J.E.; Johnson, E.F.
    Characterization of a cDNA encoding a human kidney cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli (1993), Biochim. Biophys. Acta, 1172, 161-166.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dilauroylphosphatidylcholine needs detergent Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli , human gene CYP4AII Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonic acid + NADPH + H+ + O2 Homo sapiens
-
20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
?
n-alkane + NAD(P)H + H+ + O2 Homo sapiens
-
n-alkanol + NAD(P)+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal cortex
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(n-1)-alkanoate + NADPH + H+ + O2
-
Homo sapiens (omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
?
arachidonic acid + NAD(P)H + H+ + O2
-
Homo sapiens 20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
?
arachidonic acid + NADPH + H+ + O2
-
Homo sapiens 20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
?
fatty acid + NAD(P)H + H+ + O2 pig liver NADPH-P450 reductase and cytochrome b5 are part of the system Homo sapiens omega-hydroxy fatty acid + NAD(P)+ + H2O
-
?
lauric acid + NAD(P)H + H+ + O2
-
Homo sapiens 12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
?
n-alkane + NAD(P)H + H+ + O2
-
Homo sapiens n-alkanol + NAD(P)+ + H2O
-
?
palmitic acid + NAD(P)H + H+ + O2
-
Homo sapiens 16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay conditions Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00133
-
PGA1 omega-hydroxylation Homo sapiens
0.0025
-
arachidonic acid (omega-1)-hydroxylation Homo sapiens
0.0085
-
lauric acid (omega-1)-hydroxylation Homo sapiens
0.00917
-
arachidonic acid omega-hydroxylation Homo sapiens
0.0105
-
palmitic acid (omega-1)-hydroxylation Homo sapiens
0.0367
-
palmitic acid omega-hydroxylation Homo sapiens
0.163
-
lauric acid omega-hydroxylation Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens